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Gastrointestinal Histoplasmosis Mimicking Crohn’s Disease

Disseminated histoplasmosis is a life-threatening disease usually seen in immunocompromised patients living in endemic areas. We present an apparently immunocompetent patient with gastrointestinal histoplasmosis who was initially diagnosed with biopsy-proven Crohn’s disease. Following discontinuatio...

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Detalles Bibliográficos
Autores principales: Shojaei, Esfandiar, Walsh, Joanna C, Sangle, Nikhil, Yan, Brian, Silverman, Michael S, Hosseini-Moghaddam, Seyed M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274358/
https://www.ncbi.nlm.nih.gov/pubmed/34262987
http://dx.doi.org/10.1093/ofid/ofab249
Descripción
Sumario:Disseminated histoplasmosis is a life-threatening disease usually seen in immunocompromised patients living in endemic areas. We present an apparently immunocompetent patient with gastrointestinal histoplasmosis who was initially diagnosed with biopsy-proven Crohn’s disease. Following discontinuation of anti-inflammatory drugs and institution of antifungal therapy, his gastrointestinal illness completely improved. Specific fungal staining should be routinely included in histopathologic assessment of tissue specimens diagnosed as Crohn’s disease.