T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) are the dominant stromal cell in the TME and co-localize with T cells in non-small c...

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Detalles Bibliográficos
Autores principales: O’Connor, Richard A, Chauhan, Vishwani, Mathieson, Layla, Titmarsh, Helen, Koppensteiner, Lilian, Young, Irene, Tagliavini, Guilia, Dorward, David A, Prost, Sandrine, Dhaliwal, Kevin, Wallace, William A, Akram, Ahsan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274440/
https://www.ncbi.nlm.nih.gov/pubmed/34290905
http://dx.doi.org/10.1080/2162402X.2021.1940675

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