SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses

The majority of SARS-CoV-2 vaccines in use or advanced development are based on the viral spike protein (S) as their immunogen. S is present on virions as prefusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described agains...

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Detalles Bibliográficos
Autores principales: Carnell, George W., Ciazynska, Katarzyna A., Wells, David A., Xiong, Xiaoli, Aguinam, Ernest T., McLaughlin, Stephen H., Mallery, Donna, Ebrahimi, Soraya, Ceron-Gutierrez, Lourdes, Asbach, Benedikt, Einhauser, Sebastian, Wagner, Ralf, James, Leo C., Doffinger, Rainer, Heeney, Jonathan L., Briggs, John A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274612/
https://www.ncbi.nlm.nih.gov/pubmed/33963055
http://dx.doi.org/10.1128/JVI.00203-21

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