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Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control

Obesity is commonly associated with sympathetic overdrive, which is one of the major risk factors for the development of cardiovascular diseases, such as hypertension and heart failure. Over the past few decades, there has been a growing understanding of molecular mechanisms underlying obesity devel...

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Autores principales: Deng, Yue, Deng, Guorui, Grobe, Justin L., Cui, Huxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274634/
https://www.ncbi.nlm.nih.gov/pubmed/34262481
http://dx.doi.org/10.3389/fphys.2021.691226
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author Deng, Yue
Deng, Guorui
Grobe, Justin L.
Cui, Huxing
author_facet Deng, Yue
Deng, Guorui
Grobe, Justin L.
Cui, Huxing
author_sort Deng, Yue
collection PubMed
description Obesity is commonly associated with sympathetic overdrive, which is one of the major risk factors for the development of cardiovascular diseases, such as hypertension and heart failure. Over the past few decades, there has been a growing understanding of molecular mechanisms underlying obesity development with central origin; however, the relative contribution of these molecular changes to the regulation of cardiovascular function remains vague. A variety of G-protein coupled receptors (GPCRs) and their downstream signaling pathways activated in distinct hypothalamic neurons by different metabolic hormones, neuropeptides and monoamine neurotransmitters are crucial not only for the regulation of appetite and metabolic homeostasis but also for the sympathetic control of cardiovascular function. In this review, we will highlight the main GPCRs and associated hypothalamic nuclei that are important for both metabolic homeostasis and cardiovascular function. The potential downstream molecular mediators of these GPCRs will also be discussed.
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spelling pubmed-82746342021-07-13 Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control Deng, Yue Deng, Guorui Grobe, Justin L. Cui, Huxing Front Physiol Physiology Obesity is commonly associated with sympathetic overdrive, which is one of the major risk factors for the development of cardiovascular diseases, such as hypertension and heart failure. Over the past few decades, there has been a growing understanding of molecular mechanisms underlying obesity development with central origin; however, the relative contribution of these molecular changes to the regulation of cardiovascular function remains vague. A variety of G-protein coupled receptors (GPCRs) and their downstream signaling pathways activated in distinct hypothalamic neurons by different metabolic hormones, neuropeptides and monoamine neurotransmitters are crucial not only for the regulation of appetite and metabolic homeostasis but also for the sympathetic control of cardiovascular function. In this review, we will highlight the main GPCRs and associated hypothalamic nuclei that are important for both metabolic homeostasis and cardiovascular function. The potential downstream molecular mediators of these GPCRs will also be discussed. Frontiers Media S.A. 2021-06-28 /pmc/articles/PMC8274634/ /pubmed/34262481 http://dx.doi.org/10.3389/fphys.2021.691226 Text en Copyright © 2021 Deng, Deng, Grobe and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Deng, Yue
Deng, Guorui
Grobe, Justin L.
Cui, Huxing
Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title_full Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title_fullStr Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title_full_unstemmed Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title_short Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control
title_sort hypothalamic gpcr signaling pathways in cardiometabolic control
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274634/
https://www.ncbi.nlm.nih.gov/pubmed/34262481
http://dx.doi.org/10.3389/fphys.2021.691226
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