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Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes

INTRODUCTION: This project sought to compare patient-reported outcomes between patients who received intra-operative radiation therapy (IORT) and those who qualified for IORT but received whole-breast external beam radiation therapy (EBRT) following breast-conserving surgery (BCS). METHODS: Three sc...

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Autores principales: Leatherman, Jo, Nicholas, Christina, Cusick, Therese, Cooke, Ellen, Ablah, Elizabeth, Okut, Hayrettin, Hunt, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: University of Kansas Medical Center 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274810/
https://www.ncbi.nlm.nih.gov/pubmed/34262637
http://dx.doi.org/10.17161/kjm.vol1415147
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author Leatherman, Jo
Nicholas, Christina
Cusick, Therese
Cooke, Ellen
Ablah, Elizabeth
Okut, Hayrettin
Hunt, Diane
author_facet Leatherman, Jo
Nicholas, Christina
Cusick, Therese
Cooke, Ellen
Ablah, Elizabeth
Okut, Hayrettin
Hunt, Diane
author_sort Leatherman, Jo
collection PubMed
description INTRODUCTION: This project sought to compare patient-reported outcomes between patients who received intra-operative radiation therapy (IORT) and those who qualified for IORT but received whole-breast external beam radiation therapy (EBRT) following breast-conserving surgery (BCS). METHODS: Three scales from the BREAST-Q Breast Cancer BCT Module Version 2.0 questionnaire were used to collect patient-reported outcomes regarding post-operative physical well-being of the chest, post-operative satisfaction with breast cosmesis, and post-operative adverse effects of radiation. RESULTS: Patients who received EBRT travelled farther on average than patients who received IORT to complete treatment. Respondents who received IORT reported better physical well-being of the chest than those who received EBRT. Regression revealed that the respondent’s age was the determining factor in the difference between IORT and EBRT post-operative physical well-being scores, where younger patients report poorer well-being. There was no difference in patient-reported outcomes regarding post-operative satisfaction with breast cosmesis or adverse effects of radiation. CONCLUSIONS: Patients who received IORT reported better physical well-being of the chest than patients who received EBRT. There appeared to be a relationship between age and physical well-being of chest. This study suggested that there was no difference in patient-reported outcomes concerning post-operative satisfaction with breast cosmesis or post-operative adverse effects of radiation between patients who received IORT and those who received EBRT.
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spelling pubmed-82748102021-07-13 Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes Leatherman, Jo Nicholas, Christina Cusick, Therese Cooke, Ellen Ablah, Elizabeth Okut, Hayrettin Hunt, Diane Kans J Med Original Research INTRODUCTION: This project sought to compare patient-reported outcomes between patients who received intra-operative radiation therapy (IORT) and those who qualified for IORT but received whole-breast external beam radiation therapy (EBRT) following breast-conserving surgery (BCS). METHODS: Three scales from the BREAST-Q Breast Cancer BCT Module Version 2.0 questionnaire were used to collect patient-reported outcomes regarding post-operative physical well-being of the chest, post-operative satisfaction with breast cosmesis, and post-operative adverse effects of radiation. RESULTS: Patients who received EBRT travelled farther on average than patients who received IORT to complete treatment. Respondents who received IORT reported better physical well-being of the chest than those who received EBRT. Regression revealed that the respondent’s age was the determining factor in the difference between IORT and EBRT post-operative physical well-being scores, where younger patients report poorer well-being. There was no difference in patient-reported outcomes regarding post-operative satisfaction with breast cosmesis or adverse effects of radiation. CONCLUSIONS: Patients who received IORT reported better physical well-being of the chest than patients who received EBRT. There appeared to be a relationship between age and physical well-being of chest. This study suggested that there was no difference in patient-reported outcomes concerning post-operative satisfaction with breast cosmesis or post-operative adverse effects of radiation between patients who received IORT and those who received EBRT. University of Kansas Medical Center 2021-07-09 /pmc/articles/PMC8274810/ /pubmed/34262637 http://dx.doi.org/10.17161/kjm.vol1415147 Text en © 2021 The University of Kansas Medical Center https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Research
Leatherman, Jo
Nicholas, Christina
Cusick, Therese
Cooke, Ellen
Ablah, Elizabeth
Okut, Hayrettin
Hunt, Diane
Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title_full Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title_fullStr Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title_full_unstemmed Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title_short Intra-operative Radiation Therapy versus Whole Breast External Beam Radiotherapy: A Comparison of Patient-Reported Outcomes
title_sort intra-operative radiation therapy versus whole breast external beam radiotherapy: a comparison of patient-reported outcomes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274810/
https://www.ncbi.nlm.nih.gov/pubmed/34262637
http://dx.doi.org/10.17161/kjm.vol1415147
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