Cargando…

Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke

Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not been fully investigated. Here, we examined the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Yuhualei, Tian, Dan, Wang, Huan, Zhao, Yushang, Zhang, Chengjie, Wang, Song, Xie, Dan, Zhang, Dong, Zhu, Yanbing, Zhang, Yongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274971/ https://www.ncbi.nlm.nih.gov/pubmed/34262436 http://dx.doi.org/10.3389/fncel.2021.664312

Ejemplares similares

TCRαβ(+)NK1.1(-)CD4(-)CD8(-) double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice
por: Tian, Dan, et al.
Publicado: (2023)

Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice
por: Zhang, Chengjie, et al.
Publicado: (2018)

Inhibition of phospholipase D1 ameliorates hepatocyte steatosis and non-alcoholic fatty liver disease
por: Wang, Huan, et al.
Publicado: (2023)

Perforin deficiency attenuates collagen-induced arthritis
por: Bauer, Kristin, et al.
Publicado: (2005)

Effect of Stress Hyperglycemia on Neurological Deficit and Mortality in the Acute Ischemic Stroke People With and Without Diabetes
por: Li, Jiejie, et al.
Publicado: (2020)

BK Channel-Mediated Microglial Phagocytosis Alleviates Neurological Deficit After Ischemic Stroke
por: Huang, Shuxian, et al.
Publicado: (2021)

Decitabine attenuates ischemic stroke by reducing astrocytes proliferation in rats
por: Zhang, Qi, et al.
Publicado: (2022)

Eriodictyol Attenuates MCAO-Induced Brain Injury and Neurological Deficits via Reversing the Autophagy Dysfunction
por: Wang, Chuanxiang, et al.
Publicado: (2021)

Pre-Stroke Statin Use Is Associated with Mild Neurological Deficits at the Onset of Acute Ischemic Stroke
por: Mori, Takahisa, et al.
Publicado: (2022)

FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion
por: Tian, Dai-Shi, et al.
Publicado: (2022)

A Novel Approach to Assessing the Severity of Acute Stroke and Neurological Deficits in Patients with Acute Ischemic Stroke Using Myocardial Work Echocardiography
por: Zhang, Jun, et al.
Publicado: (2022)

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo
por: Rappold, Phillip M., et al.
Publicado: (2014)

Levetiracetam Attenuates the Spinal Cord Injury Induced by Acute Trauma via Suppressing the Expression of Perforin
por: Xia, Hong, et al.
Publicado: (2022)

Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats
por: Cao, Li-Mei, et al.
Publicado: (2019)

t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke
por: Draxler, Dominik F., et al.
Publicado: (2019)

Intravenous Thrombolysis After Reversal of Dabigatran With Idarucizumab in Acute Ischemic Stroke: A Case Report
por: Xie, Dan, et al.
Publicado: (2021)

Increased Platelet-to-Lymphocyte Ratio is an Independent Predictor of Hemorrhagic Transformation and In-Hospital Mortality Among Acute Ischemic Stroke with Large-Artery Atherosclerosis Patients
por: Yang, Yi, et al.
Publicado: (2021)

Perforin and hematological cancer
por: Covas, Dimas Tadeu
Publicado: (2011)

The impact of COVID-19 on ischemic stroke
por: Zhai, Pan, et al.
Publicado: (2020)

Granzyme-A deficiency attenuates experimental osteoarthritis in mice, but perforin deficiency does not
por: Calvo, Jorge, et al.
Publicado: (2023)

Disentangling the Association Between Neurologic Deficits, Patient-Reported Impairments, and Quality of Life After Ischemic Stroke
por: van der Ende, Nadinda A.M., et al.
Publicado: (2023)

Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage
por: Cai, Jia-Chen, et al.
Publicado: (2018)

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD
por: Wang, Qian, et al.
Publicado: (2020)

The pore conformation of lymphocyte perforin
por: Ivanova, Marina E., et al.
Publicado: (2022)

Increased Uterine NK cell numbers and perforin expression during the implantation phase in IVF Cycles with GnRH Antagonist Protocol
por: Xu, Bufang, et al.
Publicado: (2017)

Estrogen and progesterone attenuate glutamate neurotoxicity via regulation of EAAT3 and GLT-1 in a rat model of ischemic stroke
por: Nematipour, Sara, et al.
Publicado: (2020)

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes
por: Tadokoro, Hiroko, et al.
Publicado: (2020)

Delayed Ischemic Neurologic Deficit after Aneurysmal Subarachnoid Hemorrhage
por: Yamaki, Vitor Nagai, et al.
Publicado: (2019)

A Multidisciplinary Algorithm for the Evaluation of Acute Neurologic Deficits Improves Management of Cryptogenic Stroke or Transient Ischemic Attack
por: Hull, Robert, et al.
Publicado: (2023)

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer
por: Chuang, C-H, et al.
Publicado: (2014)

D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis
por: Li, Mingyang, et al.
Publicado: (2022)

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity
por: Peng, Kaige, et al.
Publicado: (2016)

Perforin Gene Transfer Into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency
por: Carmo, Marlene, et al.
Publicado: (2015)

Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice
por: Seo, Ho-won, et al.
Publicado: (2023)

Dehydroascorbic Acid Attenuates Ischemic Brain Edema and Neurotoxicity in Cerebral Ischemia: An in vivo Study
por: Song, Juhyun, et al.
Publicado: (2015)

Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke
por: Cai, Biyang, et al.
Publicado: (2015)

Perforin: an important player in immune response
por: Osińska, Iwona, et al.
Publicado: (2014)

Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017)

Perforin-Like Proteins of Apicomplexan Parasites
por: Sassmannshausen, Juliane, et al.
Publicado: (2020)

Perforin and resistance to SARS coronavirus 2
por: Cunningham, Louise, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qacs7ramj8q3rl8uvkdfqnetje