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Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study

BACKGROUND: The association between vitamin D receptor (VDR) polymorphisms and metabolic syndrome (MS) has been demonstrated by epidemiological studies while their correlation remain controversial. The aim of this study is to investigate the association of VDR gene polymorphisms with MS and MS‐relat...

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Autores principales: Jin, Ting, Lu, Weina, Gong, Xiaoqin, Zhou, Jiaqiang, Wu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275005/
https://www.ncbi.nlm.nih.gov/pubmed/34008880
http://dx.doi.org/10.1002/jcla.23829
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author Jin, Ting
Lu, Weina
Gong, Xiaoqin
Zhou, Jiaqiang
Wu, Fang
author_facet Jin, Ting
Lu, Weina
Gong, Xiaoqin
Zhou, Jiaqiang
Wu, Fang
author_sort Jin, Ting
collection PubMed
description BACKGROUND: The association between vitamin D receptor (VDR) polymorphisms and metabolic syndrome (MS) has been demonstrated by epidemiological studies while their correlation remain controversial. The aim of this study is to investigate the association of VDR gene polymorphisms with MS and MS‐related components in the two communities of Hangzhou. METHODS: A total of 394 subjects were enrolled in the cross‐sectional study. Four VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) were selected based on human genome sequence databases and genotyped using the MassARRAY Analyzer Compact. RESULTS: In lipid profile, the TT genotype of ApaI had a significantly lower risk of hypertriglyceridemia compared with the GG+GT genotypes (recessive model: OR = 0.141; 95% CI = 0.041–0.486; p < 0.01) and the GG genotype (codominant model: OR = 0.155; 95% CI = 0.044–0.545; p < 0.01). The levels of triglyceride (TG) in the TT genotype of ApaI were lower than the GG+GT genotypes (1.29 ± 0.63 vs. 1.78 ± 1.59 mmol/L, p < 0.01). Furthermore, the AA+GA carriers of BsmI had lower levels of high‐density lipoprotein cholesterol (HDL‐C) than the GG carriers (1.28 ± 0.29 vs. 1.42 ± 0.34 mmol/L, p < 0.05). The CC+TC carriers of TaqI also suffered from lower HDL‐C compared with the TT carriers (1.27 ± 0.29 vs. 1.42 ± 0.34 mmol/L, p < 0.01). For arterial blood pressure, the CC carriers had lower systolic blood pressure (SBP) than the TT+TC carriers (p < 0.01) and the TT carriers of FokI (p < 0.05). However, the FokI polymorphisms were not associated with SBP and the mean blood pressure of both groups laid within the normal range. CONCLUSIONS: In our study, VDR polymorphisms show no association with the MS risk. The present results suggest that the VDR ApaI polymorphism is associated with hypertriglyceridemia and predisposed to developing MS, while the variants of BsmI and TaqI seem to affect HDL‐C. Nevertheless, the effect of FokI variants with SBP is ambiguous.
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spelling pubmed-82750052021-07-15 Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study Jin, Ting Lu, Weina Gong, Xiaoqin Zhou, Jiaqiang Wu, Fang J Clin Lab Anal Research Articles BACKGROUND: The association between vitamin D receptor (VDR) polymorphisms and metabolic syndrome (MS) has been demonstrated by epidemiological studies while their correlation remain controversial. The aim of this study is to investigate the association of VDR gene polymorphisms with MS and MS‐related components in the two communities of Hangzhou. METHODS: A total of 394 subjects were enrolled in the cross‐sectional study. Four VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) were selected based on human genome sequence databases and genotyped using the MassARRAY Analyzer Compact. RESULTS: In lipid profile, the TT genotype of ApaI had a significantly lower risk of hypertriglyceridemia compared with the GG+GT genotypes (recessive model: OR = 0.141; 95% CI = 0.041–0.486; p < 0.01) and the GG genotype (codominant model: OR = 0.155; 95% CI = 0.044–0.545; p < 0.01). The levels of triglyceride (TG) in the TT genotype of ApaI were lower than the GG+GT genotypes (1.29 ± 0.63 vs. 1.78 ± 1.59 mmol/L, p < 0.01). Furthermore, the AA+GA carriers of BsmI had lower levels of high‐density lipoprotein cholesterol (HDL‐C) than the GG carriers (1.28 ± 0.29 vs. 1.42 ± 0.34 mmol/L, p < 0.05). The CC+TC carriers of TaqI also suffered from lower HDL‐C compared with the TT carriers (1.27 ± 0.29 vs. 1.42 ± 0.34 mmol/L, p < 0.01). For arterial blood pressure, the CC carriers had lower systolic blood pressure (SBP) than the TT+TC carriers (p < 0.01) and the TT carriers of FokI (p < 0.05). However, the FokI polymorphisms were not associated with SBP and the mean blood pressure of both groups laid within the normal range. CONCLUSIONS: In our study, VDR polymorphisms show no association with the MS risk. The present results suggest that the VDR ApaI polymorphism is associated with hypertriglyceridemia and predisposed to developing MS, while the variants of BsmI and TaqI seem to affect HDL‐C. Nevertheless, the effect of FokI variants with SBP is ambiguous. John Wiley and Sons Inc. 2021-05-19 /pmc/articles/PMC8275005/ /pubmed/34008880 http://dx.doi.org/10.1002/jcla.23829 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Jin, Ting
Lu, Weina
Gong, Xiaoqin
Zhou, Jiaqiang
Wu, Fang
Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title_full Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title_fullStr Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title_full_unstemmed Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title_short Association of vitamin D receptor polymorphisms with metabolic syndrome‐related components: A cross‐sectional study
title_sort association of vitamin d receptor polymorphisms with metabolic syndrome‐related components: a cross‐sectional study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275005/
https://www.ncbi.nlm.nih.gov/pubmed/34008880
http://dx.doi.org/10.1002/jcla.23829
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