Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Peng, Zhu, Shaomi, Liang, Xin, Zhang, Qinxiu, Luo, Xiaohong, Liu, Chi, Song, Linjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275123/
https://www.ncbi.nlm.nih.gov/pubmed/34262341
http://dx.doi.org/10.2147/CMAR.S314502
_version_ 1783721667141304320
author Huang, Peng
Zhu, Shaomi
Liang, Xin
Zhang, Qinxiu
Luo, Xiaohong
Liu, Chi
Song, Linjiang
author_facet Huang, Peng
Zhu, Shaomi
Liang, Xin
Zhang, Qinxiu
Luo, Xiaohong
Liu, Chi
Song, Linjiang
author_sort Huang, Peng
collection PubMed
description Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.
format Online
Article
Text
id pubmed-8275123
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-82751232021-07-13 Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives Huang, Peng Zhu, Shaomi Liang, Xin Zhang, Qinxiu Luo, Xiaohong Liu, Chi Song, Linjiang Cancer Manag Res Review Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management. Dove 2021-07-05 /pmc/articles/PMC8275123/ /pubmed/34262341 http://dx.doi.org/10.2147/CMAR.S314502 Text en © 2021 Huang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Huang, Peng
Zhu, Shaomi
Liang, Xin
Zhang, Qinxiu
Luo, Xiaohong
Liu, Chi
Song, Linjiang
Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title_full Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title_fullStr Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title_full_unstemmed Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title_short Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
title_sort regulatory mechanisms of lncrnas in cancer glycolysis: facts and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275123/
https://www.ncbi.nlm.nih.gov/pubmed/34262341
http://dx.doi.org/10.2147/CMAR.S314502
work_keys_str_mv AT huangpeng regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT zhushaomi regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT liangxin regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT zhangqinxiu regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT luoxiaohong regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT liuchi regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives
AT songlinjiang regulatorymechanismsoflncrnasincancerglycolysisfactsandperspectives

Ejemplares similares