Cargando…

Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma

Despite recent therapeutic advances, multiple myeloma (MM) patients experience relapses as they become resistant to various classes and combinations of treatment. Melphalan (L-PAM) is an ageless drug. However, its use in the autologous stem cell transplantation (ASCT) setting and the innovative quad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morabito, Fortunato, Tripepi, Giovanni, Martino, Enrica Antonia, Vigna, Ernesto, Mendicino, Francesco, Morabito, Lucio, Todoerti, Katia, Al-Janazreh, Hamdi, D’Arrigo, Graziella, Canale, Filippo Antonio, Cutrona, Giovanna, Neri, Antonino, Martino, Massimo, Gentile, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275138/ https://www.ncbi.nlm.nih.gov/pubmed/34262262 http://dx.doi.org/10.2147/DDDT.S295215

Ejemplares similares

Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes
por: Byrgazov, Konstantin, et al.
Publicado: (2021)

The approval and withdrawal of melphalan flufenamide (melflufen): Implications for the state of the FDA.
por: Olivier, Timothée, et al.
Publicado: (2022)

Mechanisms of Immune Evasion in Multiple Myeloma: Open Questions and Therapeutic Opportunities
por: Botta, Cirino, et al.
Publicado: (2021)

Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
por: Byrgazov, Konstantin, et al.
Publicado: (2020)

Authors’ reply: Perspective: The approval and withdrawal of melphalan flufenamide (melflufen): Implications for the state of the FDA
por: Schjesvold, Fredrik H, et al.
Publicado: (2022)

Lymphocyte Doubling Time As A Key Prognostic Factor To Predict Time To First Treatment In Early-Stage Chronic Lymphocytic Leukemia
por: Morabito, Fortunato, et al.
Publicado: (2021)

Genes selection using deep learning and explainable artificial intelligence for chronic lymphocytic leukemia predicting the need and time to therapy
por: Morabito, Fortunato, et al.
Publicado: (2023)

Validation of a survival-risk score (SRS) in relapsed/refractory CLL patients treated with idelalisib–rituximab
por: Gentile, Massimo, et al.
Publicado: (2020)

Treatment of Lenalidomide Exposed or Refractory Multiple Myeloma: Network Meta-Analysis of Lenalidomide-Sparing Regimens
por: Botta, Cirino, et al.
Publicado: (2021)

Safe and Effective Administration of Caplacizumab in COVID-19-Associated Thrombotic Thrombocytopenic Purpura
por: Bruzzese, Antonella, et al.
Publicado: (2023)

Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After Allogenic Stem Cell Transplant and Dasatinib: A Case Report
por: Botta, Cirino, et al.
Publicado: (2020)

Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high-dose melphalan and autologous stem cell transplantation
por: Martino, Massimo, et al.
Publicado: (2023)

Correction to: Effectiveness of biosimilar pegfilgrastim in patients with multiple myeloma after high‑dose melphalan and autologous stem cell transplantation
por: Martino, Massimo, et al.
Publicado: (2023)

Clinical Options in Relapsed or Refractory Hodgkin Lymphoma: An Updated Review
por: Fedele, Roberta, et al.
Publicado: (2015)

Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
por: Todoerti, Katia, et al.
Publicado: (2021)

Phosphoglucomutase comes into the spotlight
por: Doello, Sofía, et al.
Publicado: (2023)

An unusual case of T-cell acute lymphoblastic leukemia in a patient with BCR-ABL positive chronic myeloid leukemia and Gaucher disease
por: Al-Janazreh, Hamdi, et al.
Publicado: (2021)

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome
por: Todoerti, Katia, et al.
Publicado: (2021)

Gravity, mass to come under the spotlight
por: Kemm, Kelvin
Publicado: (2007)

Red‐shifted optogenetics comes to the spotlight
por: Wang, Tianlu, et al.
Publicado: (2022)

Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia?
por: Molica, Stefano, et al.
Publicado: (2009)

Venous bicarbonate and CKD progression: a longitudinal analysis by the group-based trajectory model
por: D'Arrigo, Graziella, et al.
Publicado: (2023)

HIV and Aging Comes into the Spotlight: 2013 to Now
por: Taylor, Tonya
Publicado: (2020)

HIV and Aging Comes into the Spotlight: 2012 to 2015
por: Brennan-Ing, Mark
Publicado: (2020)

Sleep‐Disordered Breathing and 24‐Hour Ambulatory Blood Pressure Monitoring in Renal Transplant Patients: Longitudinal Study
por: Mallamaci, Francesca, et al.
Publicado: (2020)

Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?
por: Monti, Paola, et al.
Publicado: (2020)

Transcriptomic Analysis in Multiple Myeloma and Primary Plasma Cell Leukemia with t(11;14) Reveals Different Expression Patterns with Biological Implications in Venetoclax Sensitivity
por: Todoerti, Katia, et al.
Publicado: (2021)

Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review
por: Abd ElHafeez, Samar, et al.
Publicado: (2018)

Methods to Analyse Time-to-Event Data: The Kaplan-Meier Survival Curve
por: D'Arrigo, Graziella, et al.
Publicado: (2021)

Methods to Analyze Time-to-Event Data: The Cox Regression Analysis
por: Abd ElHafeez, Samar, et al.
Publicado: (2021)

Effectiveness of Apremilast in Real Life in Patients with Psoriasis: A Longitudinal Study
por: MALARA, Giovanna, et al.
Publicado: (2021)

Antitumor Effects of PRIMA-1 and PRIMA-1(Met) (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?
por: Menichini, Paola, et al.
Publicado: (2021)

Long-Term Changes in Sleep Disordered Breathing in Renal Transplant Patients: Relevance of the BMI
por: Mallamaci, Francesca, et al.
Publicado: (2020)

Measures of frequency and effect in clinical research
por: D’Arrigo, Graziella, et al.
Publicado: (2023)

Fundamentals and Applications of the Receiver Operating Characteristic Curve Analysis in the Research of Endothelial Dysfunction in Chronic Kidney Disease
por: Roumeliotis, Stefanos, et al.
Publicado: (2022)

Effect of a home based, low intensity, physical exercise program in older adults dialysis patients: a secondary analysis of the EXCITE trial
por: Baggetta, Rossella, et al.
Publicado: (2018)

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia
por: Ronchetti, Domenica, et al.
Publicado: (2013)

Rituximab for the treatment of patients with chronic lymphocytic leukemia
por: Gentile, M, et al.
Publicado: (2010)

Rapid response systems: are they really effective?
por: Sandroni, Claudio, et al.
Publicado: (2015)

The hidden half comes into the spotlight: Peeking inside the black box of root developmental phases
por: Siqueira, João Antonio, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3qairqh92kqn23irc434c5mfu4