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Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease

BACKGROUND: Inflammasome-induced neuroinflammation is a key contributor to the pathology of Parkinson’s disease (PD). NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation has been implicated in PD in postmortem human PD brains, indicating it as a potential target for PD treatment. Me...

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Detalles Bibliográficos
Autores principales:	Zheng, Ran, Ruan, Yang, Yan, Yiqun, Lin, Zhihao, Xue, Naijia, Yan, Yaping, Tian, Jun, Yin, Xinzhen, Pu, Jiali, Zhang, Baorong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275196/ https://www.ncbi.nlm.nih.gov/pubmed/34267535 http://dx.doi.org/10.2147/JIR.S317672

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