Cargando…

Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease

BACKGROUND: Inflammasome-induced neuroinflammation is a key contributor to the pathology of Parkinson’s disease (PD). NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation has been implicated in PD in postmortem human PD brains, indicating it as a potential target for PD treatment. Me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Ran, Ruan, Yang, Yan, Yiqun, Lin, Zhihao, Xue, Naijia, Yan, Yaping, Tian, Jun, Yin, Xinzhen, Pu, Jiali, Zhang, Baorong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275196/ https://www.ncbi.nlm.nih.gov/pubmed/34267535 http://dx.doi.org/10.2147/JIR.S317672

Ejemplares similares

ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities
por: Zheng, Ran, et al.
Publicado: (2023)

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3
por: Li, Dongsheng, et al.
Publicado: (2017)

The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases
por: Arioz, Burak Ibrahim, et al.
Publicado: (2021)

NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson’s Disease
por: Han, Qiu-Qin, et al.
Publicado: (2023)

Physiological and Pathological Functions of Neuronal Hemoglobin: A Key Underappreciated Protein in Parkinson’s Disease
por: Zheng, Ran, et al.
Publicado: (2022)

Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model
por: Huang, Shuxuan, et al.
Publicado: (2021)

Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1
por: Shaheen, Mariam J., et al.
Publicado: (2021)

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/Caspase-1/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson’s Disease
por: Rui, Wenjuan, et al.
Publicado: (2020)

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
por: Lee, Eunju, et al.
Publicado: (2018)

Early-Onset Parkinson's Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review
por: Shen, Ting, et al.
Publicado: (2019)

Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review
por: Pu, Jiali, et al.
Publicado: (2016)

Aquaporin-4 Polymorphisms Are Associated With Cognitive Performance in Parkinson’s Disease
por: Fang, Yi, et al.
Publicado: (2022)

The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson’s disease
por: Schwenkgrub, Joanna, et al.
Publicado: (2017)

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis
por: Kaushik, Deepak Kumar, et al.
Publicado: (2012)

TARGETING THE NLRP3 INFLAMMASOME IN MECHANISMS OF SLEEP DEPRIVATION-INDUCED NEUROINFLAMMATION
por: Smith, Chad, et al.
Publicado: (2019)

FERM Domain Containing Protein 7 Interacts with the Rho GDP Dissociation Inhibitor and Specifically Activates Rac1 Signaling
por: Pu, Jiali, et al.
Publicado: (2013)

Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid hemorrhage
por: Xia, Dayong, et al.
Publicado: (2023)

Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
por: Liu, Qianjin, et al.
Publicado: (2020)

lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation
por: Xue, Zhenyi, et al.
Publicado: (2018)

Itaconate Attenuates Neuroinflammation and Exerts Dopamine Neuroprotection in Parkinson’s Disease through Inhibiting NLRP3 Inflammasome
por: Sun, Guoqing, et al.
Publicado: (2022)

Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
por: Ma, Chunmei, et al.
Publicado: (2023)

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
por: Zhang, Yahui, et al.
Publicado: (2021)

GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
por: Qin, Zhangjin, et al.
Publicado: (2022)

The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle
por: Sayed, Ramy KA, et al.
Publicado: (2021)

Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome
por: Xiong, Xiaoyu, et al.
Publicado: (2022)

Age and Chronodisruption in Mouse Heart: Effect of the NLRP3 Inflammasome and Melatonin Therapy
por: Fernández-Ortiz, Marisol, et al.
Publicado: (2022)

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
por: Arioz, Burak I., et al.
Publicado: (2019)

A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease
por: Lee, Jun Ho, et al.
Publicado: (2021)

LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat
por: Valenzuela-Arzeta, Irais E., et al.
Publicado: (2023)

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease
por: Quan, Wei, et al.
Publicado: (2023)

High glucose enhances the activation of NLRP3 inflammasome by ambient fine particulate matter in alveolar macrophages
por: Mo, Yiqun, et al.
Publicado: (2023)

“Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson’s disease”
por: Rodríguez-Cruz, Alfredo, et al.
Publicado: (2019)

Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome
por: Zheng, Xue, et al.
Publicado: (2022)

Editorial: The NLRP3 inflammasome-mediated neuroinflammation and its related mitochondrial impairment in neurodegeneration
por: Deng, Chao, et al.
Publicado: (2023)

Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition
por: Ma, Sai, et al.
Publicado: (2018)

NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis
por: Bonomini, Francesca, et al.
Publicado: (2019)

Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin
por: Şehirli, Ahmet Özer, et al.
Publicado: (2021)

The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage
por: Sayed, Ramy K. A., et al.
Publicado: (2021)

Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice
por: Yu, Yongxiang, et al.
Publicado: (2021)

Hunting down NLRP3 inflammasome: An executioner of radiation-induced injury
por: Cheng, Han, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c492efeg0aaa2ijrklj6b8tl5o