Cargando…

DECODE: a Deep-learning framework for Condensing enhancers and refining boundaries with large-scale functional assays

MOTIVATION: Mapping distal regulatory elements, such as enhancers, is a cornerstone for elucidating how genetic variations may influence diseases. Previous enhancer-prediction methods have used either unsupervised approaches or supervised methods with limited training data. Moreover, past approaches...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhanlin, Zhang, Jing, Liu, Jason, Dai, Yi, Lee, Donghoon, Min, Martin Renqiang, Xu, Min, Gerstein, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Regulatory and Functional Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275369/ https://www.ncbi.nlm.nih.gov/pubmed/34252960 http://dx.doi.org/10.1093/bioinformatics/btab283

Ejemplares similares

CROTON: an automated and variant-aware deep learning framework for predicting CRISPR/Cas9 editing outcomes
por: Li, Victoria R, et al.
Publicado: (2021)

JEDI: circular RNA prediction based on junction encoders and deep interaction among splice sites
por: Jiang, Jyun-Yu, et al.
Publicado: (2021)

Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale
por: Mendelevich, Asia, et al.
Publicado: (2023)

stPlus: a reference-based method for the accurate enhancement of spatial transcriptomics
por: Shengquan, Chen, et al.
Publicado: (2021)

Resolving diverse protein–DNA footprints from exonuclease-based ChIP experiments
por: Biswas, Anushua, et al.
Publicado: (2021)

Bayesian information sharing enhances detection of regulatory associations in rare cell types
por: Wu, Alexander P, et al.
Publicado: (2021)

Predicting mechanism of action of novel compounds using compound structure and transcriptomic signature coembedding
por: Jang, Gwanghoon, et al.
Publicado: (2021)

Practical selection of representative sets of RNA-seq samples using a hierarchical approach
por: Tung, Laura H, et al.
Publicado: (2021)

scPNMF: sparse gene encoding of single cells to facilitate gene selection for targeted gene profiling
por: Song, Dongyuan, et al.
Publicado: (2021)

SAILER: scalable and accurate invariant representation learning for single-cell ATAC-seq processing and integration
por: Cao, Yingxin, et al.
Publicado: (2021)

Long reads capture simultaneous enhancer–promoter methylation status for cell-type deconvolution
por: Margalit, Sapir, et al.
Publicado: (2021)

Thermodynamic modeling reveals widespread multivalent binding by RNA-binding proteins
por: Sohrabi-Jahromi, Salma, et al.
Publicado: (2021)

Cell type matching across species using protein embeddings and transfer learning
por: Biharie, Kirti, et al.
Publicado: (2023)

CellBRF: a feature selection method for single-cell clustering using cell balance and random forest
por: Xu, Yunpei, et al.
Publicado: (2023)

An intrinsically interpretable neural network architecture for sequence-to-function learning
por: Balcı, Ali Tuğrul, et al.
Publicado: (2023)

scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
por: Burdziak, Cassandra, et al.
Publicado: (2023)

Robust reconstruction of single-cell RNA-seq data with iterative gene weight updates
por: Sheng, Yueqi, et al.
Publicado: (2023)

Reference panel-guided super-resolution inference of Hi-C data
por: Zhang, Yanlin, et al.
Publicado: (2023)

Drug Lag and Key Regulatory Barriers in the Emerging Markets
por: Wileman, Harriet, et al.
Publicado: (2010)

Regulations and guidelines governing stem cell based products: Clinical considerations
por: George, Bobby
Publicado: (2011)

Regulatory Considerations for Biosimilars
por: Nellore, Ranjani
Publicado: (2010)

Registration of Medical Devices
por: George, Bobby
Publicado: (2010)

Implications of ICH-E5: Assessment of drug's sensitivity to ethnic factors and necessity of a bridging study for global drug development
por: Gupta, Sandeep Kumar
Publicado: (2011)

Regulatory requirements for marketing fixed dose combinations
por: Jayasheel, B. G.
Publicado: (2010)

Injury and death in clinical trials and compensation: Rule 122 DAB
por: Ghooi, Ravindra. B.
Publicado: (2013)

Key points of technical review for the registration of SARS-CoV-2 antigen/antibody tests
por: Li, Hongran, et al.
Publicado: (2021)

China NMPA perspective on clinical evaluation of SARS-CoV-2 antibody test reagents in the process of emergency approval
por: Lv, Yunfeng, et al.
Publicado: (2020)

Key points of technical review for the registration of SARS-CoV-2 nucleic acid tests in China
por: Li, Hongran, et al.
Publicado: (2021)

China's NMPA perspective on the clinical performance of SARS-CoV-2 antigen test reagents
por: Lv, Yunfeng, et al.
Publicado: (2022)

Advancing a Framework for Regulatory Use of Real-World Evidence: When Real Is Reliable
por: Dreyer, Nancy A.
Publicado: (2018)

A framework for chemical safety assessment incorporating new approach methodologies within REACH
por: Ball, Nicholas, et al.
Publicado: (2022)

Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays
por: van Tongeren, Tessa C. A., et al.
Publicado: (2023)

A framework for the use of single-chemical transcriptomics data in predicting the hazards associated with complex mixtures of polycyclic aromatic hydrocarbons
por: Labib, Sarah, et al.
Publicado: (2016)

Targeting branch sites of new exons?
por: Vorechovsky, Igor
Publicado: (2012)

Paralogue annotation identifies novel pathogenic variants in patients with Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia
por: Walsh, Roddy, et al.
Publicado: (2014)

Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways
por: Schierding, William, et al.
Publicado: (2021)

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome
por: De Nittis, Pasquelena, et al.
Publicado: (2021)

Advancing in Schaaf-Yang syndrome pathophysiology: from bedside to subcellular analyses of truncated MAGEL2
por: Castilla-Vallmanya, Laura, et al.
Publicado: (2023)

Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model
por: Tonnelier, Arnaud, et al.
Publicado: (2011)

Indian Regulatory Update: Jan-May 2014
por: Suvarnapathaki, Kedar
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_p36t331qvj0imol981aggvmtl7