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The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer's disease. The available medication in the market has the ability to only slow down its progressi...

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Autores principales: Ling, Tan Sook, Chandrasegaran, Shanthini, Xuan, Low Zhi, Suan, Tong Li, Elaine, Elaine, Nathan, Durrgashini Visva, Chai, Yam Hok, Gunasekaran, Baskaran, Salvamani, Shamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275379/
https://www.ncbi.nlm.nih.gov/pubmed/34285915
http://dx.doi.org/10.1155/2021/5550938
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author Ling, Tan Sook
Chandrasegaran, Shanthini
Xuan, Low Zhi
Suan, Tong Li
Elaine, Elaine
Nathan, Durrgashini Visva
Chai, Yam Hok
Gunasekaran, Baskaran
Salvamani, Shamala
author_facet Ling, Tan Sook
Chandrasegaran, Shanthini
Xuan, Low Zhi
Suan, Tong Li
Elaine, Elaine
Nathan, Durrgashini Visva
Chai, Yam Hok
Gunasekaran, Baskaran
Salvamani, Shamala
author_sort Ling, Tan Sook
collection PubMed
description Alzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer's disease. The available medication in the market has the ability to only slow down its progression. However, nanotechnology has shown its superiority that can be applied for medical usage and it has a great potential in the therapy of Alzheimer's disease, specifically in the disease diagnosis and providing an alternative approach to treat Alzheimer's disease. This is done by increasing the efficiency of drug delivery by penetrating and overcoming the blood-brain barrier. Having said that, there are limitations that need to be further investigated and researched in order to minimize the adverse effects and potential toxicity and to improve drug bioavailability. The recent advances in the treatment of Alzheimer's disease using nanotechnology include the regeneration of stem cells, nanomedicine, and neuroprotection. In this review, we will discuss the advancement of nanotechnology which helps in the diagnosis and treatment of neurodegenerative disorders such as Alzheimer's disease as well as its challenges.
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spelling pubmed-82753792021-07-19 The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease Ling, Tan Sook Chandrasegaran, Shanthini Xuan, Low Zhi Suan, Tong Li Elaine, Elaine Nathan, Durrgashini Visva Chai, Yam Hok Gunasekaran, Baskaran Salvamani, Shamala Biomed Res Int Review Article Alzheimer's disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer's disease. The available medication in the market has the ability to only slow down its progression. However, nanotechnology has shown its superiority that can be applied for medical usage and it has a great potential in the therapy of Alzheimer's disease, specifically in the disease diagnosis and providing an alternative approach to treat Alzheimer's disease. This is done by increasing the efficiency of drug delivery by penetrating and overcoming the blood-brain barrier. Having said that, there are limitations that need to be further investigated and researched in order to minimize the adverse effects and potential toxicity and to improve drug bioavailability. The recent advances in the treatment of Alzheimer's disease using nanotechnology include the regeneration of stem cells, nanomedicine, and neuroprotection. In this review, we will discuss the advancement of nanotechnology which helps in the diagnosis and treatment of neurodegenerative disorders such as Alzheimer's disease as well as its challenges. Hindawi 2021-07-04 /pmc/articles/PMC8275379/ /pubmed/34285915 http://dx.doi.org/10.1155/2021/5550938 Text en Copyright © 2021 Tan Sook Ling et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ling, Tan Sook
Chandrasegaran, Shanthini
Xuan, Low Zhi
Suan, Tong Li
Elaine, Elaine
Nathan, Durrgashini Visva
Chai, Yam Hok
Gunasekaran, Baskaran
Salvamani, Shamala
The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title_full The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title_fullStr The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title_full_unstemmed The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title_short The Potential Benefits of Nanotechnology in Treating Alzheimer's Disease
title_sort potential benefits of nanotechnology in treating alzheimer's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275379/
https://www.ncbi.nlm.nih.gov/pubmed/34285915
http://dx.doi.org/10.1155/2021/5550938
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