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Combining Well-Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T-Lymphocyte Tetanus Toxin Epitope TT830-843

Peptide TT830-843 from the tetanus toxin is a universal T-cell epitope. It helps in vaccination and induces T-cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown. Molecular analysis of its interaction with murin...

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Detalles Bibliográficos
Autores principales:	Brandt, Artur A. M. L., Rodrigues-da-Silva, Rodrigo N., Lima-Junior, Josué C., Alves, Carlos R., de Souza-Silva, Franklin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275407/ https://www.ncbi.nlm.nih.gov/pubmed/34285916 http://dx.doi.org/10.1155/2021/5568980

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