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Modeling the Effect of Binding Kinetics in Spatial Drug Distribution in the Brain

A 3-dimensional mathematical model is developed to determine the effect of drug binding kinetics on the spatial distribution of a drug within the brain. The key components, namely, transport across the blood-brain barrier (BBB), drug distribution in the brain extracellular fluid (ECF), and drug bind...

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Detalles Bibliográficos
Autores principales:	Kashaju, Nelson, Kimathi, Mark, Masanja, Verdiana G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275424/ https://www.ncbi.nlm.nih.gov/pubmed/34285707 http://dx.doi.org/10.1155/2021/5533886

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