Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice

Gulf War Illness (GWI) is a chronic, multi-symptom peripheral and CNS condition with persistent microglial dysregulation, but the mechanisms driving the continuous neuroimmune pathology are poorly understood. The alarmin HMGB1 is an autocrine and paracrine pro-inflammatory signal, but the role of ci...

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Detalles Bibliográficos
Autores principales: Garza-Lombó, Carla, Thang, Morrent, Greve, Hendrik J., Mumaw, Christen L., Messenger, Evan J., Ahmed, Chandrama, Quinn, Emily, Sullivan, Kimberly, Block, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275600/
https://www.ncbi.nlm.nih.gov/pubmed/34253711
http://dx.doi.org/10.1038/s41398-021-01517-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275600/
https://www.ncbi.nlm.nih.gov/pubmed/34253711
http://dx.doi.org/10.1038/s41398-021-01517-1

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