Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids

New potentially biologically active sulfonamide derivatives of pentacyclic lupane-type triterpenoids, the sulfonamide group of which was bonded to C-17 of the triterpene skeleton through an amidoethane spacer, were synthesized via conjugation of 2-aminoethanesulfonamides to betulinic and betulonic a...

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Autores principales: Komissarova, N. G., Dubovitskii, S. N., Shitikova, O. V., Orlov, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275633/
https://www.ncbi.nlm.nih.gov/pubmed/34276060
http://dx.doi.org/10.1007/s10600-021-03455-2
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author Komissarova, N. G.
Dubovitskii, S. N.
Shitikova, O. V.
Orlov, A. V.
author_facet Komissarova, N. G.
Dubovitskii, S. N.
Shitikova, O. V.
Orlov, A. V.
author_sort Komissarova, N. G.
collection PubMed
description New potentially biologically active sulfonamide derivatives of pentacyclic lupane-type triterpenoids, the sulfonamide group of which was bonded to C-17 of the triterpene skeleton through an amidoethane spacer, were synthesized via conjugation of 2-aminoethanesulfonamides to betulinic and betulonic acids in the presence of Mukaiyama reagent (2-bromo-1-methylpyridinium iodide).
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spelling pubmed-82756332021-07-14 Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids Komissarova, N. G. Dubovitskii, S. N. Shitikova, O. V. Orlov, A. V. Chem Nat Compd Article New potentially biologically active sulfonamide derivatives of pentacyclic lupane-type triterpenoids, the sulfonamide group of which was bonded to C-17 of the triterpene skeleton through an amidoethane spacer, were synthesized via conjugation of 2-aminoethanesulfonamides to betulinic and betulonic acids in the presence of Mukaiyama reagent (2-bromo-1-methylpyridinium iodide). Springer US 2021-07-13 2021 /pmc/articles/PMC8275633/ /pubmed/34276060 http://dx.doi.org/10.1007/s10600-021-03455-2 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Komissarova, N. G.
Dubovitskii, S. N.
Shitikova, O. V.
Orlov, A. V.
Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title_full Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title_fullStr Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title_full_unstemmed Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title_short Synthesis of 2-Aminoethanesulfonamides of Betulinic and Betulonic Acids
title_sort synthesis of 2-aminoethanesulfonamides of betulinic and betulonic acids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275633/
https://www.ncbi.nlm.nih.gov/pubmed/34276060
http://dx.doi.org/10.1007/s10600-021-03455-2
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