Psathyrellins A–E, Antibacterial Guanacastane Diterpenoids from Mushroom Psathyrella candolleana

ABSTRACT: Five previously undescribed guanacastane diterpenoids, namely psathyrellins A–E (1–5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1–3 showed antibacterial a...

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Detalles Bibliográficos
Autores principales: Wu, Han, Yang, Hui-Xiang, Li, Zheng-Hui, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275727/
https://www.ncbi.nlm.nih.gov/pubmed/34228278
http://dx.doi.org/10.1007/s13659-021-00316-x
Descripción
Sumario:ABSTRACT: Five previously undescribed guanacastane diterpenoids, namely psathyrellins A–E (1–5), were obtained from cultures of the mushroom Psathyrella candolleana. Their structures with absolute configurations were elucidated by extensive spectroscopic methods. Compounds 1–3 showed antibacterial activity against four strains with MIC values in a range of 16–128 μg/mL. GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00316-x.

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