Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz

Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9 − 13), seven 7,17-seco-aconitine-type alkaloids (1 − 4, 6 − 8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz...

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Autores principales: Zhang, Na, Xia, Fan, Li, Song-Yu, Nian, Yin, Wei, Li-Xin, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275754/
https://www.ncbi.nlm.nih.gov/pubmed/33861417
http://dx.doi.org/10.1007/s13659-021-00302-3
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author Zhang, Na
Xia, Fan
Li, Song-Yu
Nian, Yin
Wei, Li-Xin
Xu, Gang
author_facet Zhang, Na
Xia, Fan
Li, Song-Yu
Nian, Yin
Wei, Li-Xin
Xu, Gang
author_sort Zhang, Na
collection PubMed
description Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9 − 13), seven 7,17-seco-aconitine-type alkaloids (1 − 4, 6 − 8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz. In which, flavumolines A − D (1 − 4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca(v)3.1 low voltage-gated Ca(2+) channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00302-3.
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spelling pubmed-82757542021-07-20 Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz Zhang, Na Xia, Fan Li, Song-Yu Nian, Yin Wei, Li-Xin Xu, Gang Nat Prod Bioprospect Original Article Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9 − 13), seven 7,17-seco-aconitine-type alkaloids (1 − 4, 6 − 8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz. In which, flavumolines A − D (1 − 4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Ca(v)3.1 low voltage-gated Ca(2+) channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00302-3. Springer Singapore 2021-04-16 /pmc/articles/PMC8275754/ /pubmed/33861417 http://dx.doi.org/10.1007/s13659-021-00302-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhang, Na
Xia, Fan
Li, Song-Yu
Nian, Yin
Wei, Li-Xin
Xu, Gang
Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title_full Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title_fullStr Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title_full_unstemmed Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title_short Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
title_sort diterpenoid alkaloids from the aerial parts of aconitum flavum hand.-mazz
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275754/
https://www.ncbi.nlm.nih.gov/pubmed/33861417
http://dx.doi.org/10.1007/s13659-021-00302-3
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