New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but know...

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Detalles Bibliográficos
Autores principales: Lu, Qing-Yun, Zhang, Jia-Hui, Li, Ying-Yao, Pu, Xue-Xue, Zhang, Cui-Shan, Liu, Shuai, Wan, Jia-Jia, Di, Ying-Tong, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275811/
https://www.ncbi.nlm.nih.gov/pubmed/33977511
http://dx.doi.org/10.1007/s13659-021-00309-w
Descripción
Sumario:One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC(50) of 31.9 μM. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00309-w.

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