New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but know...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Qing-Yun, Zhang, Jia-Hui, Li, Ying-Yao, Pu, Xue-Xue, Zhang, Cui-Shan, Liu, Shuai, Wan, Jia-Jia, Di, Ying-Tong, Hao, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275811/
https://www.ncbi.nlm.nih.gov/pubmed/33977511
http://dx.doi.org/10.1007/s13659-021-00309-w
_version_ 1783721784728616960
author Lu, Qing-Yun
Zhang, Jia-Hui
Li, Ying-Yao
Pu, Xue-Xue
Zhang, Cui-Shan
Liu, Shuai
Wan, Jia-Jia
Di, Ying-Tong
Hao, Xiao-Jiang
author_facet Lu, Qing-Yun
Zhang, Jia-Hui
Li, Ying-Yao
Pu, Xue-Xue
Zhang, Cui-Shan
Liu, Shuai
Wan, Jia-Jia
Di, Ying-Tong
Hao, Xiao-Jiang
author_sort Lu, Qing-Yun
collection PubMed
description One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC(50) of 31.9 μM. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00309-w.
format Online
Article
Text
id pubmed-8275811
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Singapore
record_format MEDLINE/PubMed
spelling pubmed-82758112021-07-20 New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch Lu, Qing-Yun Zhang, Jia-Hui Li, Ying-Yao Pu, Xue-Xue Zhang, Cui-Shan Liu, Shuai Wan, Jia-Jia Di, Ying-Tong Hao, Xiao-Jiang Nat Prod Bioprospect Short Communication One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC(50) of 31.9 μM. [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-021-00309-w. Springer Singapore 2021-05-11 /pmc/articles/PMC8275811/ /pubmed/33977511 http://dx.doi.org/10.1007/s13659-021-00309-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Lu, Qing-Yun
Zhang, Jia-Hui
Li, Ying-Yao
Pu, Xue-Xue
Zhang, Cui-Shan
Liu, Shuai
Wan, Jia-Jia
Di, Ying-Tong
Hao, Xiao-Jiang
New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title_full New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title_fullStr New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title_full_unstemmed New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title_short New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch
title_sort new secodaphnane-type alkaloids with cytotoxic activities from daphniphyllum angustifolium hutch
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275811/
https://www.ncbi.nlm.nih.gov/pubmed/33977511
http://dx.doi.org/10.1007/s13659-021-00309-w
work_keys_str_mv AT luqingyun newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT zhangjiahui newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT liyingyao newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT puxuexue newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT zhangcuishan newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT liushuai newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT wanjiajia newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT diyingtong newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch
AT haoxiaojiang newsecodaphnanetypealkaloidswithcytotoxicactivitiesfromdaphniphyllumangustifoliumhutch

Ejemplares similares