Cargando…

Soluble Antigen Arrays Efficiently Deliver Peptides and Arrest Spontaneous Autoimmune Diabetes

Antigen-specific immunotherapy (ASIT) offers a targeted treatment of autoimmune diseases that selectively inhibits autoreactive lymphocytes, but there remains an unmet need for approaches that address the limited clinical efficacy of ASIT. Soluble antigen arrays (SAgAs) deliver antigenic peptides or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Firdessa-Fite, Rebuma, Johnson, Stephanie N., Leon, Martin A., Khosravi-Maharlooei, Mohsen, Baker, Rocky L., Sestak, Joshua O., Berkland, Cory, Creusot, Remi J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2021
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275897/ https://www.ncbi.nlm.nih.gov/pubmed/33468513 http://dx.doi.org/10.2337/db20-0845

Ejemplares similares

Soluble antigen arrays improve the efficacy and safety of peptide-based tolerogenic immunotherapy
por: Firdessa-Fite, Rebuma, et al.
Publicado: (2023)

Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy
por: Firdessa-Fite, Rebuma, et al.
Publicado: (2019)

Preclinical evaluation of a precision medicine approach to DNA vaccination in type 1 diabetes
por: Postigo-Fernandez, Jorge, et al.
Publicado: (2022)

Epitope-based precision immunotherapy of Type 1 diabetes
por: Firdessa Fite, Rebuma, et al.
Publicado: (2023)

Efficient Presentation of Multiple Endogenous Epitopes to Both CD4(+) and CD8(+) Diabetogenic T Cells for Tolerance
por: Dastagir, Shamael R., et al.
Publicado: (2016)

Codelivery of antigen and an immune cell adhesion inhibitor is necessary for efficacy of soluble antigen arrays in experimental autoimmune encephalomyelitis
por: Sestak, Joshua O, et al.
Publicado: (2014)

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity
por: Foo, Kylie S., et al.
Publicado: (2019)

Modeling human T1D-associated autoimmune processes
por: Khosravi-Maharlooei, Mohsen, et al.
Publicado: (2021)

Chromogranin A Deficiency Confers Protection From Autoimmune Diabetes via Multiple Mechanisms
por: Srivastava, Neetu, et al.
Publicado: (2021)

Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus
por: Madley, Rachel, et al.
Publicado: (2020)

T-Cell Promiscuity in Autoimmune Diabetes
por: Li, Li, et al.
Publicado: (2008)

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
por: Delong, Thomas, et al.
Publicado: (2012)

A Humanized Mouse Model of Autoimmune Insulitis
por: Viehmann Milam, Ashley A., et al.
Publicado: (2014)

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
por: Baker, Rocky L., et al.
Publicado: (2019)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Telehealth-delivered, Cardioprotective Diet and Exercise Program for Liver Transplant Recipients: A Randomized Feasibility Study
por: Hickman, Ingrid J., et al.
Publicado: (2021)

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
por: Fiorina, Paolo, et al.
Publicado: (2008)

High Throughput Human T Cell Receptor Sequencing: A New Window Into Repertoire Establishment and Alloreactivity
por: Fu, Jianing, et al.
Publicado: (2021)

Weak Proinsulin Peptide–Major Histocompatibility Complexes Are Targeted in Autoimmune Diabetes in Mice
por: Levisetti, Matteo G., et al.
Publicado: (2008)

Children With Islet Autoimmunity and Enterovirus Infection Demonstrate a Distinct Cytokine Profile
por: Yeung, Wing-Chi G., et al.
Publicado: (2012)

Prevention of Autoimmune Diabetes by Ectopic Pancreatic β-Cell Expression of Interleukin-35
por: Bettini, Maria, et al.
Publicado: (2012)

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
por: Fourlanos, Spiros, et al.
Publicado: (2011)

The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-γ Inhibitor AS605240 in Autoimmune Diabetes
por: Azzi, Jamil, et al.
Publicado: (2012)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
por: McGuire, Helen M., et al.
Publicado: (2011)

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
por: Gerold, Kay D., et al.
Publicado: (2011)

Unfavorable transcriptome profiles and social disadvantage in hematopoietic cell transplantation: a CIBMTR analysis
por: Taylor, Mallory R., et al.
Publicado: (2023)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

HLA-DR Mismatch and Black Race Are Associated With Recurrent Autoimmune Hepatitis After Liver Transplantation
por: McCabe, Marshall, et al.
Publicado: (2021)

Fibroblast Cell-Based Therapy for Experimental Autoimmune Diabetes
por: Jalili, Reza B., et al.
Publicado: (2016)

Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01
por: Arribas-Layton, David, et al.
Publicado: (2020)

Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest
por: Longnus, Sarah L., et al.
Publicado: (2021)

Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3
por: Mamchak, Alusha A., et al.
Publicado: (2012)

Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes
por: Zhang, Chunyan, et al.
Publicado: (2010)

Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin
por: Lin, Marvin, et al.
Publicado: (2010)

Immune Regulatory Properties of Allogeneic Adipose-Derived Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Diabetes
por: Bassi, Ênio J., et al.
Publicado: (2012)

Nonviral-Mediated Hepatic Expression of IGF-I Increases Treg Levels and Suppresses Autoimmune Diabetes in Mice
por: Anguela, Xavier M., et al.
Publicado: (2013)

Deficiency of Nuclear Factor-κB c-Rel Accelerates the Development of Autoimmune Diabetes in NOD Mice
por: Ramakrishnan, Parameswaran, et al.
Publicado: (2016)

Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT
por: Geerlinks, Ashley V., et al.
Publicado: (2023)

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells
por: Silva, Diego G., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_nk1aqsgr5249o7mbl6lh8nft1t