Cargando…

Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by primary difficulties in social function. Individuals with ASD display slowed neural processing of faces, as indexed by the latency of the N170, a face-sensitive event-related potential. Currently, there are...

Descripción completa

Detalles Bibliográficos
Autores principales: Kala, Shashwat, Rolison, Max J., Trevisan, Dominic A., Naples, Adam J., Pelphrey, Kevin, Ventola, Pamela, McPartland, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275957/
https://www.ncbi.nlm.nih.gov/pubmed/34267691
http://dx.doi.org/10.3389/fpsyt.2021.709382
_version_ 1783721817102352384
author Kala, Shashwat
Rolison, Max J.
Trevisan, Dominic A.
Naples, Adam J.
Pelphrey, Kevin
Ventola, Pamela
McPartland, James C.
author_facet Kala, Shashwat
Rolison, Max J.
Trevisan, Dominic A.
Naples, Adam J.
Pelphrey, Kevin
Ventola, Pamela
McPartland, James C.
author_sort Kala, Shashwat
collection PubMed
description Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by primary difficulties in social function. Individuals with ASD display slowed neural processing of faces, as indexed by the latency of the N170, a face-sensitive event-related potential. Currently, there are no objective biomarkers of ASD useful in clinical care or research. Efficacy of behavioral treatment is currently evaluated through subjective clinical impressions. To explore whether the N170 might have utility as an objective index of treatment response, we examined N170 before and after receipt of an empirically validated behavioral treatment in children with ASD. Method: Electroencephalography (EEG) data were obtained on a preliminary cohort of preschool-aged children with ASD before and after a 16-week course of PRT and in a subset of participants in waitlist control (16-weeks before the start of PRT) and follow-up (16-weeks after the end of PRT). EEG was recorded while participants viewed computer-generated faces with neutral and fearful affect. Results: Significant reductions in N170 latency to faces were observed following 16 weeks of PRT intervention. Change in N170 latency was not observed in the waitlist-control condition. Conclusions: This exploratory study offers suggestive evidence that N170 latency may index response to behavioral treatment. Future, more rigorous, studies in larger samples are indicated to evaluate whether the N170 may be useful as a biomarker of treatment response.
format Online
Article
Text
id pubmed-8275957
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82759572021-07-14 Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder Kala, Shashwat Rolison, Max J. Trevisan, Dominic A. Naples, Adam J. Pelphrey, Kevin Ventola, Pamela McPartland, James C. Front Psychiatry Psychiatry Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by primary difficulties in social function. Individuals with ASD display slowed neural processing of faces, as indexed by the latency of the N170, a face-sensitive event-related potential. Currently, there are no objective biomarkers of ASD useful in clinical care or research. Efficacy of behavioral treatment is currently evaluated through subjective clinical impressions. To explore whether the N170 might have utility as an objective index of treatment response, we examined N170 before and after receipt of an empirically validated behavioral treatment in children with ASD. Method: Electroencephalography (EEG) data were obtained on a preliminary cohort of preschool-aged children with ASD before and after a 16-week course of PRT and in a subset of participants in waitlist control (16-weeks before the start of PRT) and follow-up (16-weeks after the end of PRT). EEG was recorded while participants viewed computer-generated faces with neutral and fearful affect. Results: Significant reductions in N170 latency to faces were observed following 16 weeks of PRT intervention. Change in N170 latency was not observed in the waitlist-control condition. Conclusions: This exploratory study offers suggestive evidence that N170 latency may index response to behavioral treatment. Future, more rigorous, studies in larger samples are indicated to evaluate whether the N170 may be useful as a biomarker of treatment response. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8275957/ /pubmed/34267691 http://dx.doi.org/10.3389/fpsyt.2021.709382 Text en Copyright © 2021 Kala, Rolison, Trevisan, Naples, Pelphrey, Ventola and McPartland. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Kala, Shashwat
Rolison, Max J.
Trevisan, Dominic A.
Naples, Adam J.
Pelphrey, Kevin
Ventola, Pamela
McPartland, James C.
Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title_full Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title_fullStr Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title_full_unstemmed Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title_short Brief Report: Preliminary Evidence of the N170 as a Biomarker of Response to Treatment in Autism Spectrum Disorder
title_sort brief report: preliminary evidence of the n170 as a biomarker of response to treatment in autism spectrum disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275957/
https://www.ncbi.nlm.nih.gov/pubmed/34267691
http://dx.doi.org/10.3389/fpsyt.2021.709382
work_keys_str_mv AT kalashashwat briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT rolisonmaxj briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT trevisandominica briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT naplesadamj briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT pelphreykevin briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT ventolapamela briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder
AT mcpartlandjamesc briefreportpreliminaryevidenceofthen170asabiomarkerofresponsetotreatmentinautismspectrumdisorder