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Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining

INTRODUCTION: There are numerous types of surgery for patients with primary gastric tumour, which can be summarized as radical surgery or palliative surgery. Different surgical procedures will have further effects for different stage of patients. AIM: We will use the resources of the SEER database (...

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Autores principales: Xu, Cheng, Chen, Qingling, Ye, Fan, Fan, Qi, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275962/
https://www.ncbi.nlm.nih.gov/pubmed/34276842
http://dx.doi.org/10.5114/pg.2021.106666
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author Xu, Cheng
Chen, Qingling
Ye, Fan
Fan, Qi
Wang, Qing
author_facet Xu, Cheng
Chen, Qingling
Ye, Fan
Fan, Qi
Wang, Qing
author_sort Xu, Cheng
collection PubMed
description INTRODUCTION: There are numerous types of surgery for patients with primary gastric tumour, which can be summarized as radical surgery or palliative surgery. Different surgical procedures will have further effects for different stage of patients. AIM: We will use the resources of the SEER database (2010–2015) to explore the therapeutic value of surgery and prognostic factors. MATERIAL AND METHODS: Kaplan-Meier analysis/log-rank testing for data analysis and multivariate analysis was conducted through a Cox proportional model. RESULTS: Fourteen thousand five hundred and seven cases of primary gastric tumours identified in the period from 2010 to 2015. In a multivariate cox regression analysis, the following factors were associated with better primary gastric patients survival (Surgical method, Age at diagnosis, histological grade). Through Kaplan-Meier analysis (p < 0.005) we also found that for the patient group the survival rate of using gastrectomy (partial, subtotal, hemi-) surgery is the lowest. CONCLUSIONS: Among patients with multivariate Cox regression model, type of surgery, age at diagnosis, and histological grade were the top 3 factors affecting patient survival. In palliative surgery, laser excision is the best surgical method of local tumour excision, and the survival of patients of this group is obviously better than in other groups. In radical surgery, near-total gastrectomy and radical gastrectomy, in continuity with the resection of other organs, are better surgical methods, while gastrectomy (partial, subtotal, hemi-) is the worst type of surgery in terms of prognosis, and even the survival rate in the later stage (after 3 years) is worse than in the group without surgery.
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spelling pubmed-82759622021-07-15 Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining Xu, Cheng Chen, Qingling Ye, Fan Fan, Qi Wang, Qing Prz Gastroenterol Original Paper INTRODUCTION: There are numerous types of surgery for patients with primary gastric tumour, which can be summarized as radical surgery or palliative surgery. Different surgical procedures will have further effects for different stage of patients. AIM: We will use the resources of the SEER database (2010–2015) to explore the therapeutic value of surgery and prognostic factors. MATERIAL AND METHODS: Kaplan-Meier analysis/log-rank testing for data analysis and multivariate analysis was conducted through a Cox proportional model. RESULTS: Fourteen thousand five hundred and seven cases of primary gastric tumours identified in the period from 2010 to 2015. In a multivariate cox regression analysis, the following factors were associated with better primary gastric patients survival (Surgical method, Age at diagnosis, histological grade). Through Kaplan-Meier analysis (p < 0.005) we also found that for the patient group the survival rate of using gastrectomy (partial, subtotal, hemi-) surgery is the lowest. CONCLUSIONS: Among patients with multivariate Cox regression model, type of surgery, age at diagnosis, and histological grade were the top 3 factors affecting patient survival. In palliative surgery, laser excision is the best surgical method of local tumour excision, and the survival of patients of this group is obviously better than in other groups. In radical surgery, near-total gastrectomy and radical gastrectomy, in continuity with the resection of other organs, are better surgical methods, while gastrectomy (partial, subtotal, hemi-) is the worst type of surgery in terms of prognosis, and even the survival rate in the later stage (after 3 years) is worse than in the group without surgery. Termedia Publishing House 2021-06-04 2021 /pmc/articles/PMC8275962/ /pubmed/34276842 http://dx.doi.org/10.5114/pg.2021.106666 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Xu, Cheng
Chen, Qingling
Ye, Fan
Fan, Qi
Wang, Qing
Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title_full Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title_fullStr Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title_full_unstemmed Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title_short Selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on Cox regression: a SEER database analysis based on data mining
title_sort selection of surgical procedures and analysis of prognostic factors in patients with primary gastric tumour based on cox regression: a seer database analysis based on data mining
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275962/
https://www.ncbi.nlm.nih.gov/pubmed/34276842
http://dx.doi.org/10.5114/pg.2021.106666
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