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The Gut Microbiota of Critically Ill Patients With COVID-19

The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being...

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Autores principales: Gaibani, Paolo, D’Amico, Federica, Bartoletti, Michele, Lombardo, Donatella, Rampelli, Simone, Fornaro, Giacomo, Coladonato, Simona, Siniscalchi, Antonio, Re, Maria Carla, Viale, Pierluigi, Brigidi, Patrizia, Turroni, Silvia, Giannella, Maddalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276076/
https://www.ncbi.nlm.nih.gov/pubmed/34268136
http://dx.doi.org/10.3389/fcimb.2021.670424
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author Gaibani, Paolo
D’Amico, Federica
Bartoletti, Michele
Lombardo, Donatella
Rampelli, Simone
Fornaro, Giacomo
Coladonato, Simona
Siniscalchi, Antonio
Re, Maria Carla
Viale, Pierluigi
Brigidi, Patrizia
Turroni, Silvia
Giannella, Maddalena
author_facet Gaibani, Paolo
D’Amico, Federica
Bartoletti, Michele
Lombardo, Donatella
Rampelli, Simone
Fornaro, Giacomo
Coladonato, Simona
Siniscalchi, Antonio
Re, Maria Carla
Viale, Pierluigi
Brigidi, Patrizia
Turroni, Silvia
Giannella, Maddalena
author_sort Gaibani, Paolo
collection PubMed
description The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections.
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spelling pubmed-82760762021-07-14 The Gut Microbiota of Critically Ill Patients With COVID-19 Gaibani, Paolo D’Amico, Federica Bartoletti, Michele Lombardo, Donatella Rampelli, Simone Fornaro, Giacomo Coladonato, Simona Siniscalchi, Antonio Re, Maria Carla Viale, Pierluigi Brigidi, Patrizia Turroni, Silvia Giannella, Maddalena Front Cell Infect Microbiol Cellular and Infection Microbiology The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8276076/ /pubmed/34268136 http://dx.doi.org/10.3389/fcimb.2021.670424 Text en Copyright © 2021 Gaibani, D’Amico, Bartoletti, Lombardo, Rampelli, Fornaro, Coladonato, Siniscalchi, Re, Viale, Brigidi, Turroni and Giannella https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Gaibani, Paolo
D’Amico, Federica
Bartoletti, Michele
Lombardo, Donatella
Rampelli, Simone
Fornaro, Giacomo
Coladonato, Simona
Siniscalchi, Antonio
Re, Maria Carla
Viale, Pierluigi
Brigidi, Patrizia
Turroni, Silvia
Giannella, Maddalena
The Gut Microbiota of Critically Ill Patients With COVID-19
title The Gut Microbiota of Critically Ill Patients With COVID-19
title_full The Gut Microbiota of Critically Ill Patients With COVID-19
title_fullStr The Gut Microbiota of Critically Ill Patients With COVID-19
title_full_unstemmed The Gut Microbiota of Critically Ill Patients With COVID-19
title_short The Gut Microbiota of Critically Ill Patients With COVID-19
title_sort gut microbiota of critically ill patients with covid-19
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276076/
https://www.ncbi.nlm.nih.gov/pubmed/34268136
http://dx.doi.org/10.3389/fcimb.2021.670424
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