Cargando…
The Gut Microbiota of Critically Ill Patients With COVID-19
The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276076/ https://www.ncbi.nlm.nih.gov/pubmed/34268136 http://dx.doi.org/10.3389/fcimb.2021.670424 |
_version_ | 1783721842619449344 |
---|---|
author | Gaibani, Paolo D’Amico, Federica Bartoletti, Michele Lombardo, Donatella Rampelli, Simone Fornaro, Giacomo Coladonato, Simona Siniscalchi, Antonio Re, Maria Carla Viale, Pierluigi Brigidi, Patrizia Turroni, Silvia Giannella, Maddalena |
author_facet | Gaibani, Paolo D’Amico, Federica Bartoletti, Michele Lombardo, Donatella Rampelli, Simone Fornaro, Giacomo Coladonato, Simona Siniscalchi, Antonio Re, Maria Carla Viale, Pierluigi Brigidi, Patrizia Turroni, Silvia Giannella, Maddalena |
author_sort | Gaibani, Paolo |
collection | PubMed |
description | The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections. |
format | Online Article Text |
id | pubmed-8276076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82760762021-07-14 The Gut Microbiota of Critically Ill Patients With COVID-19 Gaibani, Paolo D’Amico, Federica Bartoletti, Michele Lombardo, Donatella Rampelli, Simone Fornaro, Giacomo Coladonato, Simona Siniscalchi, Antonio Re, Maria Carla Viale, Pierluigi Brigidi, Patrizia Turroni, Silvia Giannella, Maddalena Front Cell Infect Microbiol Cellular and Infection Microbiology The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8276076/ /pubmed/34268136 http://dx.doi.org/10.3389/fcimb.2021.670424 Text en Copyright © 2021 Gaibani, D’Amico, Bartoletti, Lombardo, Rampelli, Fornaro, Coladonato, Siniscalchi, Re, Viale, Brigidi, Turroni and Giannella https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Gaibani, Paolo D’Amico, Federica Bartoletti, Michele Lombardo, Donatella Rampelli, Simone Fornaro, Giacomo Coladonato, Simona Siniscalchi, Antonio Re, Maria Carla Viale, Pierluigi Brigidi, Patrizia Turroni, Silvia Giannella, Maddalena The Gut Microbiota of Critically Ill Patients With COVID-19 |
title | The Gut Microbiota of Critically Ill Patients With COVID-19 |
title_full | The Gut Microbiota of Critically Ill Patients With COVID-19 |
title_fullStr | The Gut Microbiota of Critically Ill Patients With COVID-19 |
title_full_unstemmed | The Gut Microbiota of Critically Ill Patients With COVID-19 |
title_short | The Gut Microbiota of Critically Ill Patients With COVID-19 |
title_sort | gut microbiota of critically ill patients with covid-19 |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276076/ https://www.ncbi.nlm.nih.gov/pubmed/34268136 http://dx.doi.org/10.3389/fcimb.2021.670424 |
work_keys_str_mv | AT gaibanipaolo thegutmicrobiotaofcriticallyillpatientswithcovid19 AT damicofederica thegutmicrobiotaofcriticallyillpatientswithcovid19 AT bartolettimichele thegutmicrobiotaofcriticallyillpatientswithcovid19 AT lombardodonatella thegutmicrobiotaofcriticallyillpatientswithcovid19 AT rampellisimone thegutmicrobiotaofcriticallyillpatientswithcovid19 AT fornarogiacomo thegutmicrobiotaofcriticallyillpatientswithcovid19 AT coladonatosimona thegutmicrobiotaofcriticallyillpatientswithcovid19 AT siniscalchiantonio thegutmicrobiotaofcriticallyillpatientswithcovid19 AT remariacarla thegutmicrobiotaofcriticallyillpatientswithcovid19 AT vialepierluigi thegutmicrobiotaofcriticallyillpatientswithcovid19 AT brigidipatrizia thegutmicrobiotaofcriticallyillpatientswithcovid19 AT turronisilvia thegutmicrobiotaofcriticallyillpatientswithcovid19 AT giannellamaddalena thegutmicrobiotaofcriticallyillpatientswithcovid19 AT gaibanipaolo gutmicrobiotaofcriticallyillpatientswithcovid19 AT damicofederica gutmicrobiotaofcriticallyillpatientswithcovid19 AT bartolettimichele gutmicrobiotaofcriticallyillpatientswithcovid19 AT lombardodonatella gutmicrobiotaofcriticallyillpatientswithcovid19 AT rampellisimone gutmicrobiotaofcriticallyillpatientswithcovid19 AT fornarogiacomo gutmicrobiotaofcriticallyillpatientswithcovid19 AT coladonatosimona gutmicrobiotaofcriticallyillpatientswithcovid19 AT siniscalchiantonio gutmicrobiotaofcriticallyillpatientswithcovid19 AT remariacarla gutmicrobiotaofcriticallyillpatientswithcovid19 AT vialepierluigi gutmicrobiotaofcriticallyillpatientswithcovid19 AT brigidipatrizia gutmicrobiotaofcriticallyillpatientswithcovid19 AT turronisilvia gutmicrobiotaofcriticallyillpatientswithcovid19 AT giannellamaddalena gutmicrobiotaofcriticallyillpatientswithcovid19 |