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The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures

There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment. Known as tertiary lymphoid structures, these lymphoid aggregates serve as key outposts for lymphocyte recruitment, priming and acti...

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Autores principales: Li, Roger, Berglund, Anders, Zemp, Logan, Dhillon, Jasreman, Putney, Ryan, Kim, Youngchul, Jain, Rohit K., Grass, G. Daniel, Conejo-Garcia, José, Mulé, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276102/
https://www.ncbi.nlm.nih.gov/pubmed/34267760
http://dx.doi.org/10.3389/fimmu.2021.694079
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author Li, Roger
Berglund, Anders
Zemp, Logan
Dhillon, Jasreman
Putney, Ryan
Kim, Youngchul
Jain, Rohit K.
Grass, G. Daniel
Conejo-Garcia, José
Mulé, James J.
author_facet Li, Roger
Berglund, Anders
Zemp, Logan
Dhillon, Jasreman
Putney, Ryan
Kim, Youngchul
Jain, Rohit K.
Grass, G. Daniel
Conejo-Garcia, José
Mulé, James J.
author_sort Li, Roger
collection PubMed
description There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment. Known as tertiary lymphoid structures, these lymphoid aggregates serve as key outposts for lymphocyte recruitment, priming and activation. They have been linked to favorable outcomes in many tumor types, and more recently, have been shown to be effective predictors of response to immune checkpoint blockade. We have previously described a 12-chemokine (12-CK) transcriptional score which recapitulates an overwhelming enrichment for immune-related and inflammation-related genes in colorectal carcinoma. Subsequently, the 12-CK score was found to prognosticate favorable survival in multiple tumors types including melanoma, breast cancer, and bladder cancer. In the current study, we summarize the discovery and validation of the 12-CK score in various tumor types, its relationship to TLSs found within the tumor microenvironment, and explore its potential role as both a prognostic and predictive marker in the treatment of various cancers.
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spelling pubmed-82761022021-07-14 The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures Li, Roger Berglund, Anders Zemp, Logan Dhillon, Jasreman Putney, Ryan Kim, Youngchul Jain, Rohit K. Grass, G. Daniel Conejo-Garcia, José Mulé, James J. Front Immunol Immunology There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment. Known as tertiary lymphoid structures, these lymphoid aggregates serve as key outposts for lymphocyte recruitment, priming and activation. They have been linked to favorable outcomes in many tumor types, and more recently, have been shown to be effective predictors of response to immune checkpoint blockade. We have previously described a 12-chemokine (12-CK) transcriptional score which recapitulates an overwhelming enrichment for immune-related and inflammation-related genes in colorectal carcinoma. Subsequently, the 12-CK score was found to prognosticate favorable survival in multiple tumors types including melanoma, breast cancer, and bladder cancer. In the current study, we summarize the discovery and validation of the 12-CK score in various tumor types, its relationship to TLSs found within the tumor microenvironment, and explore its potential role as both a prognostic and predictive marker in the treatment of various cancers. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8276102/ /pubmed/34267760 http://dx.doi.org/10.3389/fimmu.2021.694079 Text en Copyright © 2021 Li, Berglund, Zemp, Dhillon, Putney, Kim, Jain, Grass, Conejo-Garcia and Mulé https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Roger
Berglund, Anders
Zemp, Logan
Dhillon, Jasreman
Putney, Ryan
Kim, Youngchul
Jain, Rohit K.
Grass, G. Daniel
Conejo-Garcia, José
Mulé, James J.
The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title_full The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title_fullStr The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title_full_unstemmed The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title_short The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
title_sort 12-ck score: global measurement of tertiary lymphoid structures
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276102/
https://www.ncbi.nlm.nih.gov/pubmed/34267760
http://dx.doi.org/10.3389/fimmu.2021.694079
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