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PI3K Promotes Basal Cell Carcinoma Growth Through Kinase-Induced p21 Degradation

Basal cell carcinoma (BCC) is a locally invasive epithelial cancer that is primarily driven by the Hedgehog (HH) pathway. Advanced BCCs are a critical subset of BCCs that frequently acquire resistance to Smoothened (SMO) inhibitors and identifying pathways that bypass SMO could provide alternative t...

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Detalles Bibliográficos
Autores principales:	Chow, Rachel Y., Jeon, Ung Seop, Levee, Taylor M., Kaur, Gurleen, Cedeno, Daniel P., Doan, Linda T., Atwood, Scott X.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276170/ https://www.ncbi.nlm.nih.gov/pubmed/34268113 http://dx.doi.org/10.3389/fonc.2021.668247

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