Cargando…

A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate

Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely believed to be a significant driver in differences in response to radiotherapy. While the mechanisms of radiosensitivity have been extensively studied in the laboratory, there are a lack of models whi...

Descripción completa

Detalles Bibliográficos
Autores principales:	McMahon, Stephen Joseph, Prise, Kevin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276175/ https://www.ncbi.nlm.nih.gov/pubmed/34268120 http://dx.doi.org/10.3389/fonc.2021.689112

Ejemplares similares

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage
por: McMahon, Stephen J., et al.
Publicado: (2016)

Mechanistic Modelling of Radiation Responses
por: McMahon, Stephen J., et al.
Publicado: (2019)

Biological mechanisms of gold nanoparticle radiosensitization
por: Rosa, Soraia, et al.
Publicado: (2017)

A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation
por: McMahon, Stephen J., et al.
Publicado: (2017)

Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors
por: Greenberger, Joel S., et al.
Publicado: (2014)

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy
por: Mladenov, Emil, et al.
Publicado: (2013)

Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers
por: Kinsella, Timothy J., et al.
Publicado: (2011)

A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Rheumatoid Arthritis (MEDRA): Study protocol
por: Raad, Tala, et al.
Publicado: (2022)

Flow cytometric assessment of DNA double-strand break and repair kinetics in prediction of intrinsic radiosensitivity
por: Bahreyni-Toossi, Mohammad-Taghi, et al.
Publicado: (2022)

Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway
por: Lacombe, Jerome, et al.
Publicado: (2020)

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation
por: Ghita, Mihaela, et al.
Publicado: (2017)

Harnessing Lactate Metabolism for Radiosensitization
por: Liu, Kevin X., et al.
Publicado: (2021)

Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates
por: Matsuya, Yusuke, et al.
Publicado: (2018)

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects
por: Matsuya, Yusuke, et al.
Publicado: (2019)

Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
por: Hafsi, Hind, et al.
Publicado: (2018)

Evaluating Iodine-125 DNA Damage Benchmarks of Monte Carlo DNA Damage Models
por: Thompson, Shannon J., et al.
Publicado: (2022)

Temozolomide – Just a Radiosensitizer?
por: Kaina, Bernd, et al.
Publicado: (2022)

DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications
por: Mahmood, Niaz, et al.
Publicado: (2019)

Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond
por: Orth, Michael, et al.
Publicado: (2021)

N(6)-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression
por: Navarra, Giovanna, et al.
Publicado: (2020)

Editorial: Regulators of radiosensitivity in colorectal cancer
por: Bishnupuri, Kumar, et al.
Publicado: (2022)

High-LET radiation induces large amounts of rapidly-repaired sublethal damage
por: Guerra Liberal, Francisco D. C., et al.
Publicado: (2023)

mTOR Inhibitors as Radiosensitizers in Neuroendocrine Neoplasms
por: Exner, Samantha, et al.
Publicado: (2021)

Application of Proteomics in the Discovery of Radiosensitive Cancer Biomarkers
por: Luo, Hui, et al.
Publicado: (2022)

Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
por: Alden, Ryan S., et al.
Publicado: (2022)

Estimation of relative biological effectiveness of (225)Ac compared to (177)Lu during [(225)Ac]Ac-PSMA and [(177)Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS
por: Rumiantcev, Mikhail, et al.
Publicado: (2023)

Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy
por: Yogo, Katsunori, et al.
Publicado: (2021)

Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin
por: Govoni, Marzia, et al.
Publicado: (2021)

Mechanistic insights into Lhr helicase function in DNA repair
por: Buckley, Ryan J., et al.
Publicado: (2020)

Comparison of Individual Radiosensitivity to γ-Rays and Carbon Ions
por: Shim, Grace, et al.
Publicado: (2016)

Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids
por: Ngwa, Wilfred, et al.
Publicado: (2017)

Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells
por: Brack, Eva, et al.
Publicado: (2021)

Radiosensitivity of Breast Cancer Cells Is Dependent on the Organ Microenvironment
por: Guo, Genyan, et al.
Publicado: (2022)

A review on lymphocyte radiosensitivity and its impact on radiotherapy
por: Paganetti, Harald
Publicado: (2023)

Comparison of DNA repair and radiosensitivity of different blood cell populations
por: Heylmann, Daniel, et al.
Publicado: (2021)

Low Dose Rate Radiosensitization of Hepatocellular Carcinoma In Vitro and in Patients()
por: Cuneo, Kyle C., et al.
Publicado: (2014)

DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates
por: Hanton, F., et al.
Publicado: (2019)

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer
por: Starcher, Colton L., et al.
Publicado: (2020)

Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers.
por: Herring, C. J., et al.
Publicado: (1998)

Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines
por: Choudhuri, Rajani, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_mg9qfvad1putffei84c3d02h34