Cargando…

Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug

The SARS-CoV-2 belongs to Coronaviridae family infects host cells by the interaction of its spike glycoprotein and angiotensin-converting enzyme 2 (ACE 2) of host cells. Upon entry, the virus uses its RNA dependent RNA polymerase (NSP12) for transcribing its genome to survive in the cell and spread...

Descripción completa

Detalles Bibliográficos
Autores principales:	Srikanth, Lokanathan, Sarma, Potukuchi Venkata Gurunadha Krishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Short Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276218/ https://www.ncbi.nlm.nih.gov/pubmed/34255214 http://dx.doi.org/10.1186/s43141-021-00201-7

Ejemplares similares

Isolation, purification and characterization of Cardiolipin synthase from Mycobacterium phlei {PRIVATE}
por: Sarma, Potukuchi Venkata Gurunadha Krishna, et al.
Publicado: (2013)

Novel three missense mutations observed in Von Hippel-Lindau gene in a patient reported with renal cell carcinoma
por: Kumar, Pasupuleti Santhosh, et al.
Publicado: (2013)

Phosphorylation of Staphylococcus aureus Protein-Tyrosine Kinase Affects the Function of Glucokinase and Biofilm Formation
por: Vasu, Dudipeta, et al.
Publicado: (2017)

Elevated acetate kinase (ackA) gene expression, activity, and biofilm formation observed in methicillin-resistant strains of Staphylococcus aureus (MRSA)
por: Suthi, Subbarayudu, et al.
Publicado: (2023)

Novel mutations in the kinase domain of BCR-ABL gene causing imatinib resistance in chronic myeloid leukemia patients
por: Chandrasekhar, Chodimella, et al.
Publicado: (2019)

Coronaviral RNA-methyltransferases: function, structure and inhibition
por: Nencka, Radim, et al.
Publicado: (2022)

In silico designing and molecular docking of a potent analog against Staphylococcus aureus porphobilinogen synthase
por: Kumar, Pasupuleti Santhosh, et al.
Publicado: (2014)

Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insight
por: Begum, Feroza, et al.
Publicado: (2021)

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2010)

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2011)

A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
por: Konkolova, Eva, et al.
Publicado: (2022)

Rotaviral and Coronaviral Diarrhea
por: Torres-Medina, Alfonso, et al.
Publicado: (1985)

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication
por: Oudshoorn, Diede, et al.
Publicado: (2017)

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients
por: Rabets, Andrii, et al.
Publicado: (2021)

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein
por: Littler, Dene R., et al.
Publicado: (2021)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Ferret Systemic Coronaviral Disease (FSCD)
Publicado: (2013)

In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV
por: Udofia, Inemesit A., et al.
Publicado: (2021)

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
por: Ahn, Dae-Gyun, et al.
Publicado: (2012)

The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension
por: te Velthuis, Aartjan J.W., et al.
Publicado: (2012)

In-Silico Drug Designing of Spike Receptor with Its ACE2 Receptor and Nsp10/Nsp16 MTase Complex Against SARS-CoV-2
por: Siddiqa, M A., et al.
Publicado: (2021)

Molecular characterization of α-amylase from Staphylococcus aureus
por: Lakshmi, Hanumanthu Prasanna, et al.
Publicado: (2013)

Protein Histochemistry Using Coronaviral Spike Proteins: Studying Binding Profiles and Sialic Acid Requirements for Attachment to Tissues
por: Wickramasinghe, Iresha N. Ambepitiya, et al.
Publicado: (2014)

Host proteases as determinants of coronaviral neurotropism and virulence
por: Vavougios, George D.
Publicado: (2020)

Lithium and coronaviral infections. A scoping review.
por: Nowak, Jan K., et al.
Publicado: (2020)

Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Hamilton, M.C.K., et al.
Publicado: (2020)

Neuroimmune multi-hit perspective of coronaviral infection
por: Hayley, Shawn, et al.
Publicado: (2021)

In Silico and In Vitro Identification of Pan-Coronaviral Main Protease Inhibitors from a Large Natural Product Library
por: Shahhamzehei, Nasim, et al.
Publicado: (2022)

Potential Coronaviral Inhibitors of the Nucleocapsid Protein Identified In Silico and In Vitro from a Large Natural Product Library
por: Pohler, Alexandra, et al.
Publicado: (2022)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound naringenin as a promising drug candidate against COVID-19
por: Aleebrahim-Dehkordi, Elahe, et al.
Publicado: (2023)

Cloning, expression and characterization of glucokinase gene involved in the glucose-6- phosphate formation in Staphylococcus aureus
por: Lakshmi, Hanumanthu Prasanna, et al.
Publicado: (2013)

A Computational Study on the Interaction of NSP10 and NSP14: Unraveling the RNA Synthesis Proofreading Mechanism in SARS-CoV-2, SARS-CoV, and MERS-CoV
por: Sarma, Himakshi, et al.
Publicado: (2022)

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
por: Tan, Yaw Bia, et al.
Publicado: (2022)

Interaction of Epigallocatechin Gallate and Quercetin with Spike Glycoprotein (S-Glycoprotein) of SARS-CoV-2: In Silico Study
por: Alavi, Mehran, et al.
Publicado: (2022)

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
por: Yang, Cheng-Wei, et al.
Publicado: (2017)

Andrographolide
por: Yan, Yu, et al.
Publicado: (2018)

COVID-19 and coronaviral hepatitis: evidence of collateral damage
por: Parvez, Mohammad K
Publicado: (2020)

Re: Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Morozov, S., et al.
Publicado: (2020)

Feline Infectious Peritonitis: An Immune-Mediated Coronaviral Vasculitis
por: August, John R.
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_4lmj1j0266j63s7lb4jfica4nt