Successful treatment of acquired reactive perforating collagenosis with itraconazole

BACKGROUND: Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis. CASE PRESENTATION: A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3 months. A series of serologica...

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Autores principales: Ye, Binrong, Cao, Yi, Liu, Yeqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276408/
https://www.ncbi.nlm.nih.gov/pubmed/34256825
http://dx.doi.org/10.1186/s40001-021-00542-6
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author Ye, Binrong
Cao, Yi
Liu, Yeqiang
author_facet Ye, Binrong
Cao, Yi
Liu, Yeqiang
author_sort Ye, Binrong
collection PubMed
description BACKGROUND: Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis. CASE PRESENTATION: A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3 months. A series of serological and immunological tests showed no abnormalities. A diagnosis of ARPC was based on skin biopsy findings. The patient was cured using treatment with itraconazole for 8 weeks, in the absence of a fungal infection. CONCLUSIONS: The anti-inflammatory and anti-angiogenic effects of itraconazole can have good therapeutic benefits for ARPC.
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spelling pubmed-82764082021-07-13 Successful treatment of acquired reactive perforating collagenosis with itraconazole Ye, Binrong Cao, Yi Liu, Yeqiang Eur J Med Res Case Report BACKGROUND: Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis. CASE PRESENTATION: A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3 months. A series of serological and immunological tests showed no abnormalities. A diagnosis of ARPC was based on skin biopsy findings. The patient was cured using treatment with itraconazole for 8 weeks, in the absence of a fungal infection. CONCLUSIONS: The anti-inflammatory and anti-angiogenic effects of itraconazole can have good therapeutic benefits for ARPC. BioMed Central 2021-07-13 /pmc/articles/PMC8276408/ /pubmed/34256825 http://dx.doi.org/10.1186/s40001-021-00542-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Ye, Binrong
Cao, Yi
Liu, Yeqiang
Successful treatment of acquired reactive perforating collagenosis with itraconazole
title Successful treatment of acquired reactive perforating collagenosis with itraconazole
title_full Successful treatment of acquired reactive perforating collagenosis with itraconazole
title_fullStr Successful treatment of acquired reactive perforating collagenosis with itraconazole
title_full_unstemmed Successful treatment of acquired reactive perforating collagenosis with itraconazole
title_short Successful treatment of acquired reactive perforating collagenosis with itraconazole
title_sort successful treatment of acquired reactive perforating collagenosis with itraconazole
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276408/
https://www.ncbi.nlm.nih.gov/pubmed/34256825
http://dx.doi.org/10.1186/s40001-021-00542-6
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