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Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study
BACKGROUND: Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been perfor...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276458/ https://www.ncbi.nlm.nih.gov/pubmed/34256777 http://dx.doi.org/10.1186/s12967-021-02968-2 |
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author | Wang, Hai-Yang Xu, Guo-Qing Ni, Ming-Fei Zhang, Cui-Hong Li, Xue-Lin Chang, Yi Sun, Xiao-Pei Zhang, Bing-Wei |
author_facet | Wang, Hai-Yang Xu, Guo-Qing Ni, Ming-Fei Zhang, Cui-Hong Li, Xue-Lin Chang, Yi Sun, Xiao-Pei Zhang, Bing-Wei |
author_sort | Wang, Hai-Yang |
collection | PubMed |
description | BACKGROUND: Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been performed to explore the underlying neuromechanism of cognitive reappraisal that occur on an unconscious level in PD patients. METHODS: Twenty-six patients with PD and 25 healthy controls (HC) performed a fully-verified event-block design emotional regulation task aimed at investigating responses of implicit cognitive reappraisal during an fMRI scan. Participants passively viewed negatively valanced pictures that were beforehand neutrally, positively, or adversely portrayed in the task. RESULTS: Whole-brain analysis of fMRI data showed that PD patients exhibited less activation in the right dorsolateral prefrontal cortex (dlPFC) and right dorsomedial prefrontal cortex (dmPFC) compared to HC, but presented greater activation in parietal cortex when negative pictures were preceded by positive/neutral vs negative descriptions. Simultaneously, interactive effects of Group × Condition were observed in the right amygdala across both groups. Furthermore, activation in dlPFC and dmPFC was is negatively correlated to severity of anxiety and panic in PD when negative images were preceded by non-negative vs negative descriptions. CONCLUSIONS: Emotional dysregulation in PD is likely the result of deficient activation in dlPFC and dmPFC during implicit cognitive reappraisal, in line with impaired automatic top-down regulation. Correlations between severity of anxiety and panic attack and activation of right dlPFC and dmPFC suggest that the failure to engage prefrontal region during implicit cognitive reappraisal might be associated wtih the severity of anxiety and panic; such functional patterns might be the target of possible treatments. |
format | Online Article Text |
id | pubmed-8276458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82764582021-07-13 Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study Wang, Hai-Yang Xu, Guo-Qing Ni, Ming-Fei Zhang, Cui-Hong Li, Xue-Lin Chang, Yi Sun, Xiao-Pei Zhang, Bing-Wei J Transl Med Research BACKGROUND: Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been performed to explore the underlying neuromechanism of cognitive reappraisal that occur on an unconscious level in PD patients. METHODS: Twenty-six patients with PD and 25 healthy controls (HC) performed a fully-verified event-block design emotional regulation task aimed at investigating responses of implicit cognitive reappraisal during an fMRI scan. Participants passively viewed negatively valanced pictures that were beforehand neutrally, positively, or adversely portrayed in the task. RESULTS: Whole-brain analysis of fMRI data showed that PD patients exhibited less activation in the right dorsolateral prefrontal cortex (dlPFC) and right dorsomedial prefrontal cortex (dmPFC) compared to HC, but presented greater activation in parietal cortex when negative pictures were preceded by positive/neutral vs negative descriptions. Simultaneously, interactive effects of Group × Condition were observed in the right amygdala across both groups. Furthermore, activation in dlPFC and dmPFC was is negatively correlated to severity of anxiety and panic in PD when negative images were preceded by non-negative vs negative descriptions. CONCLUSIONS: Emotional dysregulation in PD is likely the result of deficient activation in dlPFC and dmPFC during implicit cognitive reappraisal, in line with impaired automatic top-down regulation. Correlations between severity of anxiety and panic attack and activation of right dlPFC and dmPFC suggest that the failure to engage prefrontal region during implicit cognitive reappraisal might be associated wtih the severity of anxiety and panic; such functional patterns might be the target of possible treatments. BioMed Central 2021-07-13 /pmc/articles/PMC8276458/ /pubmed/34256777 http://dx.doi.org/10.1186/s12967-021-02968-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wang, Hai-Yang Xu, Guo-Qing Ni, Ming-Fei Zhang, Cui-Hong Li, Xue-Lin Chang, Yi Sun, Xiao-Pei Zhang, Bing-Wei Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title | Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title_full | Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title_fullStr | Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title_full_unstemmed | Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title_short | Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study |
title_sort | neural basis of implicit cognitive reappraisal in panic disorder: an event-related fmri study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276458/ https://www.ncbi.nlm.nih.gov/pubmed/34256777 http://dx.doi.org/10.1186/s12967-021-02968-2 |
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