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An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies

The COVID-19 pandemic has challenged authorities at different levels of government administration around the globe. When faced with diseases of this severity, it is useful for the authorities to have prediction tools to estimate in advance the impact on the health system as well as the human, materi...

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Autores principales: Vassallo, Lautaro, Perez, Ignacio A., Alvarez-Zuzek, Lucila G., Amaya, Julián, Torres, Marcos F., Valdez, Lucas D., La Rocca, Cristian E., Braunstein, Lidia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276572/
https://www.ncbi.nlm.nih.gov/pubmed/34271015
http://dx.doi.org/10.1016/j.mbs.2021.108664
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author Vassallo, Lautaro
Perez, Ignacio A.
Alvarez-Zuzek, Lucila G.
Amaya, Julián
Torres, Marcos F.
Valdez, Lucas D.
La Rocca, Cristian E.
Braunstein, Lidia A.
author_facet Vassallo, Lautaro
Perez, Ignacio A.
Alvarez-Zuzek, Lucila G.
Amaya, Julián
Torres, Marcos F.
Valdez, Lucas D.
La Rocca, Cristian E.
Braunstein, Lidia A.
author_sort Vassallo, Lautaro
collection PubMed
description The COVID-19 pandemic has challenged authorities at different levels of government administration around the globe. When faced with diseases of this severity, it is useful for the authorities to have prediction tools to estimate in advance the impact on the health system as well as the human, material, and economic resources that will be necessary. In this paper, we construct an extended Susceptible–Exposed–Infected–Recovered model that incorporates the social structure of Mar del Plata, the 4°most inhabited city in Argentina and head of the Municipality of General Pueyrredón. Moreover, we consider detailed partitions of infected individuals according to the illness severity, as well as data of local health resources, to bring predictions closer to the local reality. Tuning the corresponding epidemic parameters for COVID-19, we study an alternating quarantine strategy: a part of the population can circulate without restrictions at any time, while the rest is equally divided into two groups and goes on successive periods of normal activity and lockdown, each one with a duration of [Formula: see text] days. We also implement a random testing strategy with a threshold over the population. We found that [Formula: see text] is a good choice for the quarantine strategy since it reduces the infected population and, conveniently, it suits a weekly schedule. Focusing on the health system, projecting from the situation as of September 30, we foresee a difficulty to avoid saturation of the available ICU, given the extremely low levels of mobility that would be required. In the worst case, our model estimates that four thousand deaths would occur, of which 30% could be avoided with proper medical attention. Nonetheless, we found that aggressive testing would allow an increase in the percentage of people that can circulate without restrictions, and the medical facilities to deal with the additional critical patients would be relatively low.
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spelling pubmed-82765722021-07-14 An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies Vassallo, Lautaro Perez, Ignacio A. Alvarez-Zuzek, Lucila G. Amaya, Julián Torres, Marcos F. Valdez, Lucas D. La Rocca, Cristian E. Braunstein, Lidia A. Math Biosci Original Research Article The COVID-19 pandemic has challenged authorities at different levels of government administration around the globe. When faced with diseases of this severity, it is useful for the authorities to have prediction tools to estimate in advance the impact on the health system as well as the human, material, and economic resources that will be necessary. In this paper, we construct an extended Susceptible–Exposed–Infected–Recovered model that incorporates the social structure of Mar del Plata, the 4°most inhabited city in Argentina and head of the Municipality of General Pueyrredón. Moreover, we consider detailed partitions of infected individuals according to the illness severity, as well as data of local health resources, to bring predictions closer to the local reality. Tuning the corresponding epidemic parameters for COVID-19, we study an alternating quarantine strategy: a part of the population can circulate without restrictions at any time, while the rest is equally divided into two groups and goes on successive periods of normal activity and lockdown, each one with a duration of [Formula: see text] days. We also implement a random testing strategy with a threshold over the population. We found that [Formula: see text] is a good choice for the quarantine strategy since it reduces the infected population and, conveniently, it suits a weekly schedule. Focusing on the health system, projecting from the situation as of September 30, we foresee a difficulty to avoid saturation of the available ICU, given the extremely low levels of mobility that would be required. In the worst case, our model estimates that four thousand deaths would occur, of which 30% could be avoided with proper medical attention. Nonetheless, we found that aggressive testing would allow an increase in the percentage of people that can circulate without restrictions, and the medical facilities to deal with the additional critical patients would be relatively low. Elsevier Inc. 2022-04 2021-07-13 /pmc/articles/PMC8276572/ /pubmed/34271015 http://dx.doi.org/10.1016/j.mbs.2021.108664 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research Article
Vassallo, Lautaro
Perez, Ignacio A.
Alvarez-Zuzek, Lucila G.
Amaya, Julián
Torres, Marcos F.
Valdez, Lucas D.
La Rocca, Cristian E.
Braunstein, Lidia A.
An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title_full An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title_fullStr An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title_full_unstemmed An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title_short An epidemic model for COVID-19 transmission in Argentina: Exploration of the alternating quarantine and massive testing strategies
title_sort epidemic model for covid-19 transmission in argentina: exploration of the alternating quarantine and massive testing strategies
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276572/
https://www.ncbi.nlm.nih.gov/pubmed/34271015
http://dx.doi.org/10.1016/j.mbs.2021.108664
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