Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer

Gastric cancer (GC) is one of the most prevalent digestive malignancies. A great number of patients at first visit or post curative resections are diagnosed with widespread metastasis within the peritoneal cavity. Overwhelming evidence has demonstrated that exosomes, a variety of biologically functi...

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Autores principales: Chen, Xiangliu, Wang, Haiyong, Huang, Yingying, Chen, Yanyan, Chen, Chuanzhi, Zhuo, Wei, Teng, Lisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276633/
https://www.ncbi.nlm.nih.gov/pubmed/34268118
http://dx.doi.org/10.3389/fonc.2021.684871
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author Chen, Xiangliu
Wang, Haiyong
Huang, Yingying
Chen, Yanyan
Chen, Chuanzhi
Zhuo, Wei
Teng, Lisong
author_facet Chen, Xiangliu
Wang, Haiyong
Huang, Yingying
Chen, Yanyan
Chen, Chuanzhi
Zhuo, Wei
Teng, Lisong
author_sort Chen, Xiangliu
collection PubMed
description Gastric cancer (GC) is one of the most prevalent digestive malignancies. A great number of patients at first visit or post curative resections are diagnosed with widespread metastasis within the peritoneal cavity. Overwhelming evidence has demonstrated that exosomes, a variety of biologically functional extracellular vesicles comprising active factors, mediate the progression and metastasis of GC. Although the regulatory mechanisms of exosomes remain fairly elusive, they are responsible for intercellular communication between tumor cells and normal stroma, cancer-related fibroblasts, immune cells within the primary tumor and metastatic niche. In this review, we provide new insight into the molecular signatures of GC-associated exosomes in reprogramming the tumor microenvironment and the subsequent promotion of peritoneal metastasis—including infiltration of the gastric wall, implantation of tumor cells onto the pre-metastatic peritoneum, and remodeling of the pre-metastatic niche. Based on this review, we hope to draw a more general conclusion for the functions of exosomes in the progression and peritoneal metastasis of GC and highlight the future perspective on strategies targeting exosomes in prognostic biomarkers and therapy for peritoneal metastasis.
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spelling pubmed-82766332021-07-14 Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer Chen, Xiangliu Wang, Haiyong Huang, Yingying Chen, Yanyan Chen, Chuanzhi Zhuo, Wei Teng, Lisong Front Oncol Oncology Gastric cancer (GC) is one of the most prevalent digestive malignancies. A great number of patients at first visit or post curative resections are diagnosed with widespread metastasis within the peritoneal cavity. Overwhelming evidence has demonstrated that exosomes, a variety of biologically functional extracellular vesicles comprising active factors, mediate the progression and metastasis of GC. Although the regulatory mechanisms of exosomes remain fairly elusive, they are responsible for intercellular communication between tumor cells and normal stroma, cancer-related fibroblasts, immune cells within the primary tumor and metastatic niche. In this review, we provide new insight into the molecular signatures of GC-associated exosomes in reprogramming the tumor microenvironment and the subsequent promotion of peritoneal metastasis—including infiltration of the gastric wall, implantation of tumor cells onto the pre-metastatic peritoneum, and remodeling of the pre-metastatic niche. Based on this review, we hope to draw a more general conclusion for the functions of exosomes in the progression and peritoneal metastasis of GC and highlight the future perspective on strategies targeting exosomes in prognostic biomarkers and therapy for peritoneal metastasis. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8276633/ /pubmed/34268118 http://dx.doi.org/10.3389/fonc.2021.684871 Text en Copyright © 2021 Chen, Wang, Huang, Chen, Chen, Zhuo and Teng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Xiangliu
Wang, Haiyong
Huang, Yingying
Chen, Yanyan
Chen, Chuanzhi
Zhuo, Wei
Teng, Lisong
Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title_full Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title_fullStr Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title_full_unstemmed Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title_short Comprehensive Roles and Future Perspectives of Exosomes in Peritoneal Metastasis of Gastric Cancer
title_sort comprehensive roles and future perspectives of exosomes in peritoneal metastasis of gastric cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276633/
https://www.ncbi.nlm.nih.gov/pubmed/34268118
http://dx.doi.org/10.3389/fonc.2021.684871
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