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Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status
OBJECTIVE: Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276653/ https://www.ncbi.nlm.nih.gov/pubmed/34236283 http://dx.doi.org/10.1080/13510002.2021.1952819 |
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author | Maksimova, Marina Yurievna Ivanov, Alexander Vladimirovich Virus, Edward Danielevich Nikiforova, Ksenya Alexandrovna Ochtova, Fatima Ramazanovna Suanova, Ekaterina Taymurazovna Kruglova, Maria Petrovna Piradov, Mikhail Aleksanrovich Kubatiev, Aslan Amirkhanovich |
author_facet | Maksimova, Marina Yurievna Ivanov, Alexander Vladimirovich Virus, Edward Danielevich Nikiforova, Ksenya Alexandrovna Ochtova, Fatima Ramazanovna Suanova, Ekaterina Taymurazovna Kruglova, Maria Petrovna Piradov, Mikhail Aleksanrovich Kubatiev, Aslan Amirkhanovich |
author_sort | Maksimova, Marina Yurievna |
collection | PubMed |
description | OBJECTIVE: Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in patients with an acute period. PATIENTS AND METHODS: A total of 177 patients were examined. Total and reduced forms of LMWTs were determined in the first 10–24 h. Stroke severity and functional state were estimated using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRs) at admission and after 21 days. RESULTS: Patients with high levels of total Hcy (> 19 μM) showed significantly reduced redox statuses of all LMWTs. Patients with low total GSH levels (≤ 1.07 μM) were at an increased risk of higher stroke severity (NIHSS > 10) compared to patients with a total GSH level > 2.64 μM (age/gender-adjusted odds ratio: 4.69, 95% CI: 1.43–15.4). DISCUSSION: (1) low total GSH level can be considered as a novel risk marker for the severity of acute stroke in conditions of low redox status of LMWTs and (2) high Hcy levels associated with low redox status of LMWTs. |
format | Online Article Text |
id | pubmed-8276653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-82766532021-07-20 Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status Maksimova, Marina Yurievna Ivanov, Alexander Vladimirovich Virus, Edward Danielevich Nikiforova, Ksenya Alexandrovna Ochtova, Fatima Ramazanovna Suanova, Ekaterina Taymurazovna Kruglova, Maria Petrovna Piradov, Mikhail Aleksanrovich Kubatiev, Aslan Amirkhanovich Redox Rep Research Article OBJECTIVE: Acute brain ischemia is accompanied by a disruption of low-molecular-weight aminothiols (LMWTs) homeostasis, such as homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). We investigated the redox balance of LMWTs in blood plasma and its influence on ischemic stroke severity and the functional outcome in patients with an acute period. PATIENTS AND METHODS: A total of 177 patients were examined. Total and reduced forms of LMWTs were determined in the first 10–24 h. Stroke severity and functional state were estimated using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRs) at admission and after 21 days. RESULTS: Patients with high levels of total Hcy (> 19 μM) showed significantly reduced redox statuses of all LMWTs. Patients with low total GSH levels (≤ 1.07 μM) were at an increased risk of higher stroke severity (NIHSS > 10) compared to patients with a total GSH level > 2.64 μM (age/gender-adjusted odds ratio: 4.69, 95% CI: 1.43–15.4). DISCUSSION: (1) low total GSH level can be considered as a novel risk marker for the severity of acute stroke in conditions of low redox status of LMWTs and (2) high Hcy levels associated with low redox status of LMWTs. Taylor & Francis 2021-07-08 /pmc/articles/PMC8276653/ /pubmed/34236283 http://dx.doi.org/10.1080/13510002.2021.1952819 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Maksimova, Marina Yurievna Ivanov, Alexander Vladimirovich Virus, Edward Danielevich Nikiforova, Ksenya Alexandrovna Ochtova, Fatima Ramazanovna Suanova, Ekaterina Taymurazovna Kruglova, Maria Petrovna Piradov, Mikhail Aleksanrovich Kubatiev, Aslan Amirkhanovich Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title | Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title_full | Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title_fullStr | Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title_full_unstemmed | Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title_short | Impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
title_sort | impact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276653/ https://www.ncbi.nlm.nih.gov/pubmed/34236283 http://dx.doi.org/10.1080/13510002.2021.1952819 |
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