A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization

Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models and clinical trials is often less effective than predicted by CAR construct selection in two-dimensional (2D) cocultures. Three-dimensional (3D) solid tumor architecture is likely to be crucial for CAR T cell eff...

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Detalles Bibliográficos
Autores principales: Grunewald, Laura, Lam, Tobias, Andersch, Lena, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Gauert, Anton, Heeren-Hagemann, Anja I., Astrahantseff, Kathy, Klironomos, Filippos, Thomas, Alexander, Deubzer, Hedwig E., Henssen, Anton G., Eggert, Angelika, Schulte, Johannes H., Anders, Kathleen, Kloke, Lutz, Künkele, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276678/
https://www.ncbi.nlm.nih.gov/pubmed/34267756
http://dx.doi.org/10.3389/fimmu.2021.689697

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