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High-Level Production of Lysine in the Yeast Saccharomyces cerevisiae by Rational Design of Homocitrate Synthase

Homocitrate synthase (HCS) catalyzes the aldol condensation of 2-oxoglutarate (2-OG) and acetyl coenzyme A (AcCoA) to form homocitrate, which is the first enzyme of the lysine biosynthetic pathway in the yeast Saccharomyces cerevisiae. The HCS activity is tightly regulated via feedback inhibition by...

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Detalles Bibliográficos
Autores principales:	Isogai, Shota, Matsushita, Tomonori, Imanishi, Hiroyuki, Koonthongkaew, Jirasin, Toyokawa, Yoichi, Nishimura, Akira, Yi, Xiao, Kazlauskas, Romas, Takagi, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276798/ https://www.ncbi.nlm.nih.gov/pubmed/33990312 http://dx.doi.org/10.1128/AEM.00600-21

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