The Yeast eIF2 Kinase Gcn2 Facilitates H(2)O(2)-Mediated Feedback Inhibition of Both Protein Synthesis and Endoplasmic Reticulum Oxidative Folding during Recombinant Protein Production

Recombinant protein production is a known source of oxidative stress. However, knowledge of which reactive oxygen species are involved or the specific growth phase in which stress occurs remains lacking. Using modern, hypersensitive genetic H(2)O(2)-specific probes, microcultivation, and continuous...

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Detalles Bibliográficos
Autores principales: Gast, Veronica, Campbell, Kate, Picazo, Cecilia, Engqvist, Martin, Siewers, Verena, Molin, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276805/
https://www.ncbi.nlm.nih.gov/pubmed/34047633
http://dx.doi.org/10.1128/AEM.00301-21

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