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Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience

Objective: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is an established and effective therapy for primary refractory dystonia. However, the comparison of frameless vs. frame-based DBS surgery technique is still controversial. This retrospective study aims to compare the clin...

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Autores principales: Eleopra, Roberto, Rinaldo, Sara, Devigili, Grazia, Mondani, Massimo, D'Auria, Stanislao, Golfrè Andreasi, Nico, Skrap, Miran, Lettieri, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276885/
https://www.ncbi.nlm.nih.gov/pubmed/34267717
http://dx.doi.org/10.3389/fneur.2021.643757
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author Eleopra, Roberto
Rinaldo, Sara
Devigili, Grazia
Mondani, Massimo
D'Auria, Stanislao
Golfrè Andreasi, Nico
Skrap, Miran
Lettieri, Christian
author_facet Eleopra, Roberto
Rinaldo, Sara
Devigili, Grazia
Mondani, Massimo
D'Auria, Stanislao
Golfrè Andreasi, Nico
Skrap, Miran
Lettieri, Christian
author_sort Eleopra, Roberto
collection PubMed
description Objective: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is an established and effective therapy for primary refractory dystonia. However, the comparison of frameless vs. frame-based DBS surgery technique is still controversial. This retrospective study aims to compare the clinical outcome of two GPi-DBS surgical techniques for patients affected by primary generalized or multi-segmental dystonia. Methods: For lead's stereotaxic placement, 10 patients underwent frame-based surgery and the other 10 subjects DBS surgery with a frameless technique. Clinical features were evaluated at baseline and 6 and 12 months after surgery by means of the Burke–Fahn–Marsden Dystonia Rating Scale. Results: Frame-based GPi-DBS and frameless stereotaxic group revealed a comparable clinical outcome with no surgical complications. Conclusions: Frameless technique is safe and well-tolerated by patients and showed similar effectiveness of the frame-based stereotaxic surgery during GPi-DBS for primary dystonia. Notably, it could be a valid alternative solution because of the great advantage in improving the patient's discomfort during awake surgery.
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spelling pubmed-82768852021-07-14 Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience Eleopra, Roberto Rinaldo, Sara Devigili, Grazia Mondani, Massimo D'Auria, Stanislao Golfrè Andreasi, Nico Skrap, Miran Lettieri, Christian Front Neurol Neurology Objective: Bilateral globus pallidus internus deep brain stimulation (GPi-DBS) is an established and effective therapy for primary refractory dystonia. However, the comparison of frameless vs. frame-based DBS surgery technique is still controversial. This retrospective study aims to compare the clinical outcome of two GPi-DBS surgical techniques for patients affected by primary generalized or multi-segmental dystonia. Methods: For lead's stereotaxic placement, 10 patients underwent frame-based surgery and the other 10 subjects DBS surgery with a frameless technique. Clinical features were evaluated at baseline and 6 and 12 months after surgery by means of the Burke–Fahn–Marsden Dystonia Rating Scale. Results: Frame-based GPi-DBS and frameless stereotaxic group revealed a comparable clinical outcome with no surgical complications. Conclusions: Frameless technique is safe and well-tolerated by patients and showed similar effectiveness of the frame-based stereotaxic surgery during GPi-DBS for primary dystonia. Notably, it could be a valid alternative solution because of the great advantage in improving the patient's discomfort during awake surgery. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8276885/ /pubmed/34267717 http://dx.doi.org/10.3389/fneur.2021.643757 Text en Copyright © 2021 Eleopra, Rinaldo, Devigili, Mondani, D'Auria, Golfrè Andreasi, Skrap and Lettieri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Eleopra, Roberto
Rinaldo, Sara
Devigili, Grazia
Mondani, Massimo
D'Auria, Stanislao
Golfrè Andreasi, Nico
Skrap, Miran
Lettieri, Christian
Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title_full Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title_fullStr Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title_full_unstemmed Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title_short Globus Pallidus Internus Deep Brain Stimulation Using Frame-Based vs. Frameless Stereotaxy in Dystonia: A Single-Center Experience
title_sort globus pallidus internus deep brain stimulation using frame-based vs. frameless stereotaxy in dystonia: a single-center experience
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276885/
https://www.ncbi.nlm.nih.gov/pubmed/34267717
http://dx.doi.org/10.3389/fneur.2021.643757
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