Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development

Ca(2+)/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunct...

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Detalles Bibliográficos
Autores principales: Cui, Changhao, Wang, Chen, Cao, Min, Kang, Xunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276974/
https://www.ncbi.nlm.nih.gov/pubmed/34263253
http://dx.doi.org/10.33696/immunology.3.091
Descripción
Sumario:Ca(2+)/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca(2+)/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study.

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