Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development

Ca(2+)/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunct...

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Detalles Bibliográficos
Autores principales: Cui, Changhao, Wang, Chen, Cao, Min, Kang, Xunlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276974/
https://www.ncbi.nlm.nih.gov/pubmed/34263253
http://dx.doi.org/10.33696/immunology.3.091
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author Cui, Changhao
Wang, Chen
Cao, Min
Kang, Xunlei
author_facet Cui, Changhao
Wang, Chen
Cao, Min
Kang, Xunlei
author_sort Cui, Changhao
collection PubMed
description Ca(2+)/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca(2+)/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study.
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spelling pubmed-82769742021-07-13 Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development Cui, Changhao Wang, Chen Cao, Min Kang, Xunlei J Cell Immunol Article Ca(2+)/calmodulin (CaM) signaling is important for a wide range of cellular functions. It is not surprised the role of this signaling has been recognized in tumor progressions, such as proliferation, invasion, and migration. However, its role in leukemia has not been well appreciated. The multifunctional Ca(2+)/CaM-dependent protein kinases (CaMKs) are critical intermediates of this signaling and play key roles in cancer development. The most investigated CaMKs in leukemia, especially myeloid leukemia, are CaMKI, CaMKII, and CaMKIV. The function and mechanism of these kinases in leukemia development are summarized in this study. 2021 /pmc/articles/PMC8276974/ /pubmed/34263253 http://dx.doi.org/10.33696/immunology.3.091 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Cui, Changhao
Wang, Chen
Cao, Min
Kang, Xunlei
Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title_full Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title_fullStr Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title_full_unstemmed Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title_short Ca(2+)/calmodulin-dependent Protein Kinases in Leukemia Development
title_sort ca(2+)/calmodulin-dependent protein kinases in leukemia development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276974/
https://www.ncbi.nlm.nih.gov/pubmed/34263253
http://dx.doi.org/10.33696/immunology.3.091
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AT wangchen ca2calmodulindependentproteinkinasesinleukemiadevelopment
AT caomin ca2calmodulindependentproteinkinasesinleukemiadevelopment
AT kangxunlei ca2calmodulindependentproteinkinasesinleukemiadevelopment

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