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Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis

BACKGROUND: The purpose herein, was to perform a systematic review of interventional outcome studies in patients with in-hospital cardiac arrest before and during the coronavirus disease 2019 (COVID-19) pandemic period. METHODS: A meta-analysis was performed of publications meeting the following PIC...

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Autores principales: Szarpak, Lukasz, Borkowska, Magdalena, Peacock, Frank W., Rafique, Zubaid, Gasecka, Aleksandra, Smereka, Jacek, Pytkowska, Katarzyna, Jachowicz, Marta, Iskrzycki, Lukasz, Gilis-Malinowska, Natasza, Jaguszewski, Milosz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Via Medica 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277004/
https://www.ncbi.nlm.nih.gov/pubmed/33942278
http://dx.doi.org/10.5603/CJ.a2021.0043
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author Szarpak, Lukasz
Borkowska, Magdalena
Peacock, Frank W.
Rafique, Zubaid
Gasecka, Aleksandra
Smereka, Jacek
Pytkowska, Katarzyna
Jachowicz, Marta
Iskrzycki, Lukasz
Gilis-Malinowska, Natasza
Jaguszewski, Milosz J.
author_facet Szarpak, Lukasz
Borkowska, Magdalena
Peacock, Frank W.
Rafique, Zubaid
Gasecka, Aleksandra
Smereka, Jacek
Pytkowska, Katarzyna
Jachowicz, Marta
Iskrzycki, Lukasz
Gilis-Malinowska, Natasza
Jaguszewski, Milosz J.
author_sort Szarpak, Lukasz
collection PubMed
description BACKGROUND: The purpose herein, was to perform a systematic review of interventional outcome studies in patients with in-hospital cardiac arrest before and during the coronavirus disease 2019 (COVID-19) pandemic period. METHODS: A meta-analysis was performed of publications meeting the following PICOS criteria: (1) participants, patients > 18 years of age with cardiac arrest due to any causes; (2) intervention, cardiac arrest in COVID-19 period; (3) comparison, cardiac arrest in pre-COVID-19 period; (4) outcomes, detailed information for survival; (5) study design, randomized controlled trials, quasi-randomized or observational studies comparing cardiac arrest in COVID-19 and pre-COVID-19 period for their effects in patients with cardiac arrest. RESULTS: Survival to hospital discharge for the pre-pandemic and pandemic period was reported in 3 studies (n =1432 patients) and was similar in the pre-pandemic vs. the pandemic period, 35.6% vs. 32.1%, respectively (odds ratio [OR] 1.72; 95% confidence interval [CI] 0.81–3.65; p = 0.16; I(2) = 72%). Return of spontaneous circulation was reported by all 4 studies and were also similar in the pre and during COVID-19 periods, 51.9% vs. 48.7% (OR 1.27; 95% CI 0.78–2.07; p = 0.33; I(2) = 71%), respectively. Pooled analysis of cardiac arrest recurrence was also similar, 24.9% and 17.9% (OR 1.60; 95% CI 0.99–2.57; p = 0.06; I(2) = 32%) in the pre and during COVID-19 cohorts. Survival with Cerebral Performance Category 1 or 2 was higher in pre vs. during pandemic groups (27.3 vs. 9.1%; OR 3.75; 95% CI 1.26–11.20; p = 0.02). Finally, overall mortality was similar in the pre vs. pandemic groups, 65.9% and 67.2%, respectively (OR 0.67; 95% CI 0.33–1.34; p = 0.25; I(2) = 76%). CONCLUSIONS: Compared to the pre-pandemic period, in hospital cardiac arrest in COVID-19 patients was numerically higher but had statistically similar outcomes.
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spelling pubmed-82770042021-07-14 Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis Szarpak, Lukasz Borkowska, Magdalena Peacock, Frank W. Rafique, Zubaid Gasecka, Aleksandra Smereka, Jacek Pytkowska, Katarzyna Jachowicz, Marta Iskrzycki, Lukasz Gilis-Malinowska, Natasza Jaguszewski, Milosz J. Cardiol J COVID-19 BACKGROUND: The purpose herein, was to perform a systematic review of interventional outcome studies in patients with in-hospital cardiac arrest before and during the coronavirus disease 2019 (COVID-19) pandemic period. METHODS: A meta-analysis was performed of publications meeting the following PICOS criteria: (1) participants, patients > 18 years of age with cardiac arrest due to any causes; (2) intervention, cardiac arrest in COVID-19 period; (3) comparison, cardiac arrest in pre-COVID-19 period; (4) outcomes, detailed information for survival; (5) study design, randomized controlled trials, quasi-randomized or observational studies comparing cardiac arrest in COVID-19 and pre-COVID-19 period for their effects in patients with cardiac arrest. RESULTS: Survival to hospital discharge for the pre-pandemic and pandemic period was reported in 3 studies (n =1432 patients) and was similar in the pre-pandemic vs. the pandemic period, 35.6% vs. 32.1%, respectively (odds ratio [OR] 1.72; 95% confidence interval [CI] 0.81–3.65; p = 0.16; I(2) = 72%). Return of spontaneous circulation was reported by all 4 studies and were also similar in the pre and during COVID-19 periods, 51.9% vs. 48.7% (OR 1.27; 95% CI 0.78–2.07; p = 0.33; I(2) = 71%), respectively. Pooled analysis of cardiac arrest recurrence was also similar, 24.9% and 17.9% (OR 1.60; 95% CI 0.99–2.57; p = 0.06; I(2) = 32%) in the pre and during COVID-19 cohorts. Survival with Cerebral Performance Category 1 or 2 was higher in pre vs. during pandemic groups (27.3 vs. 9.1%; OR 3.75; 95% CI 1.26–11.20; p = 0.02). Finally, overall mortality was similar in the pre vs. pandemic groups, 65.9% and 67.2%, respectively (OR 0.67; 95% CI 0.33–1.34; p = 0.25; I(2) = 76%). CONCLUSIONS: Compared to the pre-pandemic period, in hospital cardiac arrest in COVID-19 patients was numerically higher but had statistically similar outcomes. Via Medica 2021-07-06 /pmc/articles/PMC8277004/ /pubmed/33942278 http://dx.doi.org/10.5603/CJ.a2021.0043 Text en Copyright © 2021 Via Medica https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
spellingShingle COVID-19
Szarpak, Lukasz
Borkowska, Magdalena
Peacock, Frank W.
Rafique, Zubaid
Gasecka, Aleksandra
Smereka, Jacek
Pytkowska, Katarzyna
Jachowicz, Marta
Iskrzycki, Lukasz
Gilis-Malinowska, Natasza
Jaguszewski, Milosz J.
Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title_full Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title_fullStr Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title_full_unstemmed Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title_short Characteristics and outcomes of in-hospital cardiac arrest in COVID-19. A systematic review and meta-analysis
title_sort characteristics and outcomes of in-hospital cardiac arrest in covid-19. a systematic review and meta-analysis
topic COVID-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277004/
https://www.ncbi.nlm.nih.gov/pubmed/33942278
http://dx.doi.org/10.5603/CJ.a2021.0043
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