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The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016

OBJECTIVES: Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan. METHODS: This was...

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Autores principales: Siddig, Omayma, Mustafa, Mayson B., Kordofani, Yousif, Gibson, John, Suleiman, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277047/
https://www.ncbi.nlm.nih.gov/pubmed/34255799
http://dx.doi.org/10.1371/journal.pone.0254634
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author Siddig, Omayma
Mustafa, Mayson B.
Kordofani, Yousif
Gibson, John
Suleiman, Ahmed M.
author_facet Siddig, Omayma
Mustafa, Mayson B.
Kordofani, Yousif
Gibson, John
Suleiman, Ahmed M.
author_sort Siddig, Omayma
collection PubMed
description OBJECTIVES: Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan. METHODS: This was a retrospective cross-sectional study conducted at Khartoum Dermatological and Venereal Diseases Teaching Hospital. We used routinely collected health care data, and included all patients with an autoimmune bullous disease who presented to the hospital between 2001 and 2016. RESULTS: Out of the 4736 patients who were admitted to the hospital during the study period, 923 (19.5%) had an autoimmune bullous disease. The average rate of patients at the hospital was 57.7 per year representing 1.3 per 100,000 population per year. After exclusion of patients where the final diagnosis was missing, 585 were included in the further analysis. Pemphigus vulgaris was the most common disease (50.9%), followed by bullous pemphigoid (28.2%), linear IgA disease/chronic bullous disease of childhood (8.4%), and pemphigus foliaceous (8.2%). Pemphigoid gestationis and IgA pemphigus constituted 1.4% and 1.2% of the cohort, respectively. Paraneoplastic pemphigus, mucous membrane pemphigoid, lichen planus pemphigoidis, bullous systemic lupus erythematosus, and dermatitis herpetiformis were rare. None of the patients had epidermolysis bullosa acquisita. CONCLUSIONS: The clinico-epidemiological characteristics vary among the types of autoimmune bullous diseases. Females were more predominant in most of them. Sudanese patients tended in general to present at a younger age than other populations. The pool of Sudanese patients with autoimmune bullous diseases is large which requires investigation for the local risk factors and presents a field for future trials.
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spelling pubmed-82770472021-07-20 The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016 Siddig, Omayma Mustafa, Mayson B. Kordofani, Yousif Gibson, John Suleiman, Ahmed M. PLoS One Research Article OBJECTIVES: Autoimmune bullous diseases vary in their clinico-epidemiological features and burden across populations. Data about these diseases was lacking in Sudan. We aimed to describe the epidemiological profile and to estimate the burden of autoimmune bullous diseases in Sudan. METHODS: This was a retrospective cross-sectional study conducted at Khartoum Dermatological and Venereal Diseases Teaching Hospital. We used routinely collected health care data, and included all patients with an autoimmune bullous disease who presented to the hospital between 2001 and 2016. RESULTS: Out of the 4736 patients who were admitted to the hospital during the study period, 923 (19.5%) had an autoimmune bullous disease. The average rate of patients at the hospital was 57.7 per year representing 1.3 per 100,000 population per year. After exclusion of patients where the final diagnosis was missing, 585 were included in the further analysis. Pemphigus vulgaris was the most common disease (50.9%), followed by bullous pemphigoid (28.2%), linear IgA disease/chronic bullous disease of childhood (8.4%), and pemphigus foliaceous (8.2%). Pemphigoid gestationis and IgA pemphigus constituted 1.4% and 1.2% of the cohort, respectively. Paraneoplastic pemphigus, mucous membrane pemphigoid, lichen planus pemphigoidis, bullous systemic lupus erythematosus, and dermatitis herpetiformis were rare. None of the patients had epidermolysis bullosa acquisita. CONCLUSIONS: The clinico-epidemiological characteristics vary among the types of autoimmune bullous diseases. Females were more predominant in most of them. Sudanese patients tended in general to present at a younger age than other populations. The pool of Sudanese patients with autoimmune bullous diseases is large which requires investigation for the local risk factors and presents a field for future trials. Public Library of Science 2021-07-13 /pmc/articles/PMC8277047/ /pubmed/34255799 http://dx.doi.org/10.1371/journal.pone.0254634 Text en © 2021 Siddig et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Siddig, Omayma
Mustafa, Mayson B.
Kordofani, Yousif
Gibson, John
Suleiman, Ahmed M.
The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title_full The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title_fullStr The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title_full_unstemmed The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title_short The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016
title_sort epidemiology of autoimmune bullous diseases in sudan between 2000 and 2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277047/
https://www.ncbi.nlm.nih.gov/pubmed/34255799
http://dx.doi.org/10.1371/journal.pone.0254634
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