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Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters

Abcg2/Bcrp and Abcb1a/Pgp are xenobiotic efflux transporters limiting substrate permeability in the gastrointestinal system and brain, and increasing renal and hepatic drug clearance. The systemic impact of Bcrp and Pgp ablation on metabolic homeostasis of endogenous substrates is incompletely under...

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Detalles Bibliográficos
Autores principales:	Ganguly, Samit, Finkelstein, David, Shaw, Timothy I., Michalek, Ryan D., Zorn, Kimberly M., Ekins, Sean, Yasuda, Kazuto, Fukuda, Yu, Schuetz, John D., Mukherjee, Kamalika, Schuetz, Erin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277073/ https://www.ncbi.nlm.nih.gov/pubmed/34255797 http://dx.doi.org/10.1371/journal.pone.0253852

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