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Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis

The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the...

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Autores principales: Stephen, Ruth, Ngandu, Tiia, Liu, Yawu, Peltonen, Markku, Antikainen, Riitta, Kemppainen, Nina, Laatikainen, Tiina, Lötjönen, Jyrki, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277089/
https://www.ncbi.nlm.nih.gov/pubmed/33970268
http://dx.doi.org/10.1093/gerona/glab130
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author Stephen, Ruth
Ngandu, Tiia
Liu, Yawu
Peltonen, Markku
Antikainen, Riitta
Kemppainen, Nina
Laatikainen, Tiina
Lötjönen, Jyrki
Rinne, Juha
Strandberg, Timo
Tuomilehto, Jaakko
Vanninen, Ritva
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
author_facet Stephen, Ruth
Ngandu, Tiia
Liu, Yawu
Peltonen, Markku
Antikainen, Riitta
Kemppainen, Nina
Laatikainen, Tiina
Lötjönen, Jyrki
Rinne, Juha
Strandberg, Timo
Tuomilehto, Jaakko
Vanninen, Ritva
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
author_sort Stephen, Ruth
collection PubMed
description The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60–77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer’s disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group × CAIDE change interaction β coefficient = −0.40, p = .02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies.
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spelling pubmed-82770892021-07-14 Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis Stephen, Ruth Ngandu, Tiia Liu, Yawu Peltonen, Markku Antikainen, Riitta Kemppainen, Nina Laatikainen, Tiina Lötjönen, Jyrki Rinne, Juha Strandberg, Timo Tuomilehto, Jaakko Vanninen, Ritva Soininen, Hilkka Kivipelto, Miia Solomon, Alina J Gerontol A Biol Sci Med Sci THE JOURNAL OF GERONTOLOGY: Biological Sciences The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60–77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer’s disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group × CAIDE change interaction β coefficient = −0.40, p = .02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies. Oxford University Press 2021-05-10 /pmc/articles/PMC8277089/ /pubmed/33970268 http://dx.doi.org/10.1093/gerona/glab130 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle THE JOURNAL OF GERONTOLOGY: Biological Sciences
Stephen, Ruth
Ngandu, Tiia
Liu, Yawu
Peltonen, Markku
Antikainen, Riitta
Kemppainen, Nina
Laatikainen, Tiina
Lötjönen, Jyrki
Rinne, Juha
Strandberg, Timo
Tuomilehto, Jaakko
Vanninen, Ritva
Soininen, Hilkka
Kivipelto, Miia
Solomon, Alina
Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title_full Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title_fullStr Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title_full_unstemmed Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title_short Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis
title_sort change in caide dementia risk score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis
topic THE JOURNAL OF GERONTOLOGY: Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277089/
https://www.ncbi.nlm.nih.gov/pubmed/33970268
http://dx.doi.org/10.1093/gerona/glab130
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