Cargando…

Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is hallmarked by social-emotional reciprocity deficits. Social-emotional responding requires the clear recognition of social cues as well as the internal monitoring of emotional salience. Insular cortex is central to the salience network, and plays a key role in approa...

Descripción completa

Detalles Bibliográficos
Autores principales: JD, Cohen, T, Smith, K, Thompson, A, Collins, TA, Knaus, H, Tager-Flusberg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277119/
https://www.ncbi.nlm.nih.gov/pubmed/34263174
http://dx.doi.org/10.18314/abne.v1i1.1120
_version_ 1783722017870053376
author JD, Cohen
T, Smith
K, Thompson
A, Collins
TA, Knaus
H, Tager-Flusberg
author_facet JD, Cohen
T, Smith
K, Thompson
A, Collins
TA, Knaus
H, Tager-Flusberg
author_sort JD, Cohen
collection PubMed
description Autism Spectrum Disorder (ASD) is hallmarked by social-emotional reciprocity deficits. Social-emotional responding requires the clear recognition of social cues as well as the internal monitoring of emotional salience. Insular cortex is central to the salience network, and plays a key role in approach-avoidance emotional valuation. Consistent right anterior insular hypoactivity and variable volumetric differences of insular cortical volumes were shown previously. The current study analyzed anterior and posterior insular volume/asymmetry changes in ASD across age. Age was used as an additional grouping variable as previous studies indicated differential regional volume in ASD individuals before and after puberty onset. In the current sample, pre-teen ASD expressed left lateralized anterior insula, while adolescent ASD had right lateralization. Typically developing (TD) individuals expressed the opposite lateralization of anterior insula in both age-groups (right greater than left anterior insular volume among pre-teen TD and left greater than right anterior insular volume among adolescent TD). Social-emotional calibrated severity scores from the ADOS were positively correlated with leftward anterior insular asymmetry and negatively correlated with proportional right anterior insular volumes in ASD. Insular cortex has a lateralized role in autonomic nervous system regulation (parasympathetic control in the left, sympathetic control in the right). Atypical insular asymmetry in ASD may contribute to the development of networks with a diminished salience signal to human faces and voices, and may lead to more learned passive avoidant responses to such stimuli at younger ages, leading to more distressed responses in adolescence. Data here supports the use of early behavioral intervention to increase awareness of and reward for social-emotional cues.
format Online
Article
Text
id pubmed-8277119
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-82771192021-07-13 Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder JD, Cohen T, Smith K, Thompson A, Collins TA, Knaus H, Tager-Flusberg Ann Behav Neurosci Article Autism Spectrum Disorder (ASD) is hallmarked by social-emotional reciprocity deficits. Social-emotional responding requires the clear recognition of social cues as well as the internal monitoring of emotional salience. Insular cortex is central to the salience network, and plays a key role in approach-avoidance emotional valuation. Consistent right anterior insular hypoactivity and variable volumetric differences of insular cortical volumes were shown previously. The current study analyzed anterior and posterior insular volume/asymmetry changes in ASD across age. Age was used as an additional grouping variable as previous studies indicated differential regional volume in ASD individuals before and after puberty onset. In the current sample, pre-teen ASD expressed left lateralized anterior insula, while adolescent ASD had right lateralization. Typically developing (TD) individuals expressed the opposite lateralization of anterior insula in both age-groups (right greater than left anterior insular volume among pre-teen TD and left greater than right anterior insular volume among adolescent TD). Social-emotional calibrated severity scores from the ADOS were positively correlated with leftward anterior insular asymmetry and negatively correlated with proportional right anterior insular volumes in ASD. Insular cortex has a lateralized role in autonomic nervous system regulation (parasympathetic control in the left, sympathetic control in the right). Atypical insular asymmetry in ASD may contribute to the development of networks with a diminished salience signal to human faces and voices, and may lead to more learned passive avoidant responses to such stimuli at younger ages, leading to more distressed responses in adolescence. Data here supports the use of early behavioral intervention to increase awareness of and reward for social-emotional cues. 2018-06-13 2018 /pmc/articles/PMC8277119/ /pubmed/34263174 http://dx.doi.org/10.18314/abne.v1i1.1120 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
JD, Cohen
T, Smith
K, Thompson
A, Collins
TA, Knaus
H, Tager-Flusberg
Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title_full Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title_fullStr Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title_full_unstemmed Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title_short Altered Anterior Insular Asymmetry in Pre-teen and Adolescent Youth with Autism Spectrum Disorder
title_sort altered anterior insular asymmetry in pre-teen and adolescent youth with autism spectrum disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277119/
https://www.ncbi.nlm.nih.gov/pubmed/34263174
http://dx.doi.org/10.18314/abne.v1i1.1120
work_keys_str_mv AT jdcohen alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder
AT tsmith alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder
AT kthompson alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder
AT acollins alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder
AT taknaus alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder
AT htagerflusberg alteredanteriorinsularasymmetryinpreteenandadolescentyouthwithautismspectrumdisorder