Quantitative Method for the Analysis of Ivacaftor, Hydroxymethyl Ivacaftor, Ivacaftor Carboxylate, Lumacaftor, and Tezacaftor in Plasma and Sputum Using Liquid Chromatography With Tandem Mass Spectrometry and Its Clinical Applicability

BACKGROUND: The novel cystic fibrosis transmembrane conductance regulator (CFTR) modulators, ivacaftor, lumacaftor, and tezacaftor, are the first drugs directly targeting the underlying pathophysiological mechanism in cystic fibrosis (CF); however, independent studies describing their pharmacokineti...

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Detalles Bibliográficos
Autores principales: Vonk, Steffie E. M., van der Meer-Vos, Marloes, Bos, Lieuwe D. J., Neerincx, Anne H., Majoor, Christof J., Maitland-van der Zee, Anke-Hilse, Mathôt, Ron A. A., Kemper, E. Marleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277188/
https://www.ncbi.nlm.nih.gov/pubmed/33165217
http://dx.doi.org/10.1097/FTD.0000000000000829

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