Cargando…

Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women

CONTEXT: The ideal therapy for endometriosis (EM) and uterine fibroids (UFs) would suppress estrogenic drive to the endometrium and myometrium, while minimizing vasomotor symptoms and bone loss associated with current treatments. An integrated neurokinin-kisspeptin system involving substance P and n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pawsey, Steve, Mills, Edouard Gregory, Ballantyne, Elizabeth, Donaldson, Kirsteen, Kerr, Mary, Trower, Mike, Dhillo, Waljit Singh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Online Only Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277204/ https://www.ncbi.nlm.nih.gov/pubmed/33624806 http://dx.doi.org/10.1210/clinem/dgab108

Ejemplares similares

SUN-LB58 Repeated Once-Daily Administration of the Non-Hormonal Neurokinin 1,3 Receptor Antagonist NT-814 Reduces LH, Estradiol and Progesterone in Healthy Women
por: Dhillo, Waljit Singh, et al.
Publicado: (2020)

Effects of NT-814, a dual neurokinin 1 and 3 receptor antagonist, on vasomotor symptoms in postmenopausal women: a placebo-controlled, randomized trial
por: Trower, Mike, et al.
Publicado: (2020)

Efficacy and safety of elinzanetant, a selective neurokinin-1,3 receptor antagonist for vasomotor symptoms: a dose-finding clinical trial (SWITCH-1)
por: Simon, James A., et al.
Publicado: (2023)

OR11-03 NT-814, a Non-Hormonal Dual Neurokinin 1,3 Receptor Antagonist Markedly Improves Vasomotor Symptoms in Post-Menopausal Women; Results of a Randomised, Double-Blind, Placebo-Controlled, Dose-Finding Study (SWITCH-1)
por: Simon, James, et al.
Publicado: (2020)

Treating hot flushes with a neurokinin 3 receptor antagonist
por: Prague, Julia K., et al.
Publicado: (2017)

Neurokinin 3 Receptor Antagonists Do Not Increase FSH or Estradiol Secretion in Menopausal Women
por: Prague, Julia K, et al.
Publicado: (2019)

Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
por: Fraser, Graeme L, et al.
Publicado: (2021)

Targeting Elevated GnRH Pulsatility to Treat Polycystic Ovary Syndrome
por: Abbara, Ali, et al.
Publicado: (2021)

Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men
por: Ohlsson, Claes, et al.
Publicado: (2021)

Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health
por: Mills, Edouard G., et al.
Publicado: (2022)

Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
por: Schmitz, Daniel, et al.
Publicado: (2021)

Corrigendum to: Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
Publicado: (2021)

Estradiol and HDL Function in Women – A Partnership for Life
por: Beazer, Jack D, et al.
Publicado: (2021)

Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications
por: Abbara, Ali, et al.
Publicado: (2021)

Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study
por: Larsson, Susanna C, et al.
Publicado: (2021)

Transgender Girls Grow Tall: Adult Height Is Unaffected by GnRH Analogue and Estradiol Treatment
por: Boogers, Lidewij Sophia, et al.
Publicado: (2022)

Neurokinin 1 Receptor Antagonists for Pruritus
por: Alam, Majid, et al.
Publicado: (2021)

Colocalization of Cocaine- and Amphetamine-Regulated Transcript with Kisspeptin and Neurokinin B in the Human Infundibular Region
por: Skrapits, Katalin, et al.
Publicado: (2014)

Neurokinin B Administration Induces Hot Flushes in Women
por: Jayasena, Channa N., et al.
Publicado: (2015)

Substance P Immunoreactivity Exhibits Frequent Colocalization with Kisspeptin and Neurokinin B in the Human Infundibular Region
por: Hrabovszky, Erik, et al.
Publicado: (2013)

The Medical Research Council (UK)/Uganda Virus Research Institute Uganda Research Unit on AIDS – ‘25 years of research through partnerships’
por: Kaleebu, P, et al.
Publicado: (2015)

Cognitive Function of Children and Adolescents With Congenital Adrenal Hyperplasia: Importance of Early Diagnosis
por: Messina, Valeria, et al.
Publicado: (2020)

Changes in orthodontics during the COVID-19 pandemic that have come to stay
por: García-Camba, Pablo, et al.
Publicado: (2020)

COVID-19: What do we know?
por: Marshall, Steve, et al.
Publicado: (2020)

Bridging worldviews: Toward a common model of leadership across the health professions
por: Garman, Andrew N., et al.
Publicado: (2020)

IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction
por: Joustra, Sjoerd D, et al.
Publicado: (2019)

Urine Steroid Metabolomics as a Novel Tool for Detection of Recurrent Adrenocortical Carcinoma
por: Chortis, Vasileios, et al.
Publicado: (2019)

Evaluation of the 2015 ATA Guidelines in Patients With Distant Metastatic Differentiated Thyroid Cancer
por: van Velsen, Evert F S, et al.
Publicado: (2019)

Bone Mineral Density After Transitioning From Denosumab to Alendronate
por: Kendler, David, et al.
Publicado: (2019)

Divergent Metastatic Patterns Between Subtypes of Thyroid Carcinoma Results From the Nationwide Dutch Pathology Registry
por: Hugen, Niek, et al.
Publicado: (2019)

Surgery as a Viable Alternative First-Line Treatment for Prolactinoma Patients. A Systematic Review and Meta-Analysis
por: Zamanipoor Najafabadi, Amir H, et al.
Publicado: (2019)

Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth
por: Nokoff, Natalie J, et al.
Publicado: (2019)

Estimated Association Between Cytokines and the Progression to Diabetes: 10-year Follow-Up From a Community-Based Cohort
por: Cho, Nam H, et al.
Publicado: (2019)

Distribution of Tri-Ponderal Mass Index and its Relation to Body Mass Index in Children and Adolescents Aged 10 to 20 Years
por: Park, Hong Kyu, et al.
Publicado: (2020)

Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation
por: Sun, Lijuan, et al.
Publicado: (2020)

Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System
por: Gideon, Angelina, et al.
Publicado: (2019)

Newly diagnosed and previously treated multicentric Castleman disease respond equally to siltuximab
por: van Rhee, Frits, et al.
Publicado: (2020)

Surgical management of a perforated ‘black oesophagus’
por: Kuiper, Gino M., et al.
Publicado: (2021)

Pembrolizumab combined with carfilzomib and low‐dose dexamethasone for relapsed or refractory multiple myeloma: Cohort 2 of the phase I KEYNOTE‐023 study
por: Moreau, Philippe, et al.
Publicado: (2021)

Cohort Profile: COVIDMENT: COVID-19 cohorts on mental health across six nations
por: Unnarsdóttir, Anna Bára, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gclhg2v09qnpldri1qlohqkqcq