Cargando…

Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes

Chronic prurigo is a debilitating skin disease characterized by the presence of chronic pruritus and scratching-related pruriginous lesions. The pruriginous lesions can differ in their clinics what has recently been categorized into different clinical phenotypes. The most common one is chronic nodul...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeidler, Claudia, Pereira, Manuel Pedro, Ständer, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277241/
https://www.ncbi.nlm.nih.gov/pubmed/34268319
http://dx.doi.org/10.3389/fmed.2021.649332
_version_ 1783722039928946688
author Zeidler, Claudia
Pereira, Manuel Pedro
Ständer, Sonja
author_facet Zeidler, Claudia
Pereira, Manuel Pedro
Ständer, Sonja
author_sort Zeidler, Claudia
collection PubMed
description Chronic prurigo is a debilitating skin disease characterized by the presence of chronic pruritus and scratching-related pruriginous lesions. The pruriginous lesions can differ in their clinics what has recently been categorized into different clinical phenotypes. The most common one is chronic nodular prurigo (syn. prurigo nodularis); other phenotypes are papular, plaque, umbilicated, and linear prurigo. A comparison between these phenotypes regarding similarities and differences has not yet been performed. In this explorative analysis, itch characteristics, scratching behavior, and disease burden of the nodular, papular, plaque, and umbilicated prurigo were investigated in 1,128 patients. Patients with nodular and plaque prurigo were younger than patients with papular and umbilicated prurigo. The shortest duration of the underlying pruritus was found in papular and umbilicated prurigo, the longest in plaque prurigo. Itch intensity, impairment of sleep, mood and the quality of life did not differ. These findings confirm that the clinical phenotypes of chronic prurigo belong to a spectrum of one disease with similar disease characteristics and can be categorized under the umbrella term of chronic prurigo. Future clinical trials should include all phenotypes of chronic prurigo.
format Online
Article
Text
id pubmed-8277241
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82772412021-07-14 Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes Zeidler, Claudia Pereira, Manuel Pedro Ständer, Sonja Front Med (Lausanne) Medicine Chronic prurigo is a debilitating skin disease characterized by the presence of chronic pruritus and scratching-related pruriginous lesions. The pruriginous lesions can differ in their clinics what has recently been categorized into different clinical phenotypes. The most common one is chronic nodular prurigo (syn. prurigo nodularis); other phenotypes are papular, plaque, umbilicated, and linear prurigo. A comparison between these phenotypes regarding similarities and differences has not yet been performed. In this explorative analysis, itch characteristics, scratching behavior, and disease burden of the nodular, papular, plaque, and umbilicated prurigo were investigated in 1,128 patients. Patients with nodular and plaque prurigo were younger than patients with papular and umbilicated prurigo. The shortest duration of the underlying pruritus was found in papular and umbilicated prurigo, the longest in plaque prurigo. Itch intensity, impairment of sleep, mood and the quality of life did not differ. These findings confirm that the clinical phenotypes of chronic prurigo belong to a spectrum of one disease with similar disease characteristics and can be categorized under the umbrella term of chronic prurigo. Future clinical trials should include all phenotypes of chronic prurigo. Frontiers Media S.A. 2021-06-29 /pmc/articles/PMC8277241/ /pubmed/34268319 http://dx.doi.org/10.3389/fmed.2021.649332 Text en Copyright © 2021 Zeidler, Pereira and Ständer. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zeidler, Claudia
Pereira, Manuel Pedro
Ständer, Sonja
Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title_full Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title_fullStr Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title_full_unstemmed Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title_short Chronic Prurigo: Similar Clinical Profile and Burden Across Clinical Phenotypes
title_sort chronic prurigo: similar clinical profile and burden across clinical phenotypes
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277241/
https://www.ncbi.nlm.nih.gov/pubmed/34268319
http://dx.doi.org/10.3389/fmed.2021.649332
work_keys_str_mv AT zeidlerclaudia chronicprurigosimilarclinicalprofileandburdenacrossclinicalphenotypes
AT pereiramanuelpedro chronicprurigosimilarclinicalprofileandburdenacrossclinicalphenotypes
AT standersonja chronicprurigosimilarclinicalprofileandburdenacrossclinicalphenotypes