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Machine Learning Uses Chemo-Transcriptomic Profiles to Stratify Antimalarial Compounds With Similar Mode of Action

The rapid development of antimalarial resistance motivates the continued search for novel compounds with a mode of action (MoA) different to current antimalarials. Phenotypic screening has delivered thousands of promising hit compounds without prior knowledge of the compounds’ exact target or MoA. W...

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Detalles Bibliográficos
Autores principales:	van Heerden, Ashleigh, van Wyk, Roelof, Birkholtz, Lyn-Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277430/ https://www.ncbi.nlm.nih.gov/pubmed/34268139 http://dx.doi.org/10.3389/fcimb.2021.688256

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