Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

The translocase of the outer mitochondrial membrane TOM constitutes the organellar entry gate for nearly all precursor proteins synthesized on cytosolic ribosomes. Thus, TOM presents the ideal target to adjust the mitochondrial proteome upon changing cellular demands. Here, we identify that the impo...

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Detalles Bibliográficos
Autores principales: Walter, Corvin, Marada, Adinarayana, Suhm, Tamara, Ernsberger, Ralf, Muders, Vera, Kücükköse, Cansu, Sánchez-Martín, Pablo, Hu, Zehan, Aich, Abhishek, Loroch, Stefan, Solari, Fiorella Andrea, Poveda-Huertes, Daniel, Schwierzok, Alexandra, Pommerening, Henrike, Matic, Stanka, Brix, Jan, Sickmann, Albert, Kraft, Claudine, Dengjel, Jörn, Dennerlein, Sven, Brummer, Tilman, Vögtle, F.-Nora, Meisinger, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277783/
https://www.ncbi.nlm.nih.gov/pubmed/34257281
http://dx.doi.org/10.1038/s41467-021-24426-9

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