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Dentate granule cells encode auditory decisions after reinforcement learning in rats
Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its possible...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277790/ https://www.ncbi.nlm.nih.gov/pubmed/34257342 http://dx.doi.org/10.1038/s41598-021-93721-8 |
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author | Shen, Jia Yao, Pan-Tong Ge, Shaoyu Xiong, Qiaojie |
author_facet | Shen, Jia Yao, Pan-Tong Ge, Shaoyu Xiong, Qiaojie |
author_sort | Shen, Jia |
collection | PubMed |
description | Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its possible involvement in transforming sensory inputs to the goal-oriented decisions. Here, we developed an auditory discrimination task in which rats learned to navigate to goal locations based on the frequencies of auditory stimuli. Using in vivo calcium imaging in freely behaving rats over the course of learning, we found that dentate granule cells became more active, spatially tuned, and responsive to task-related variables as learning progressed. Furthermore, only after task learning, the activity of dentate granule cell ensembles represented the navigation path and predicts auditory decisions as early as when rats began to approach the goals. Finally, chemogenetic silencing of dentate gyrus suppressed task learning. Our results demonstrate that dentate granule cells gain task-relevant firing pattern through reinforcement learning and could be a potential link of sensory decisions to spatial navigation. |
format | Online Article Text |
id | pubmed-8277790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82777902021-07-15 Dentate granule cells encode auditory decisions after reinforcement learning in rats Shen, Jia Yao, Pan-Tong Ge, Shaoyu Xiong, Qiaojie Sci Rep Article Auditory-cued goal-oriented behaviors requires the participation of cortical and subcortical brain areas, but how neural circuits associate sensory-based decisions with goal locations through learning remains poorly understood. The hippocampus is critical for spatial coding, suggesting its possible involvement in transforming sensory inputs to the goal-oriented decisions. Here, we developed an auditory discrimination task in which rats learned to navigate to goal locations based on the frequencies of auditory stimuli. Using in vivo calcium imaging in freely behaving rats over the course of learning, we found that dentate granule cells became more active, spatially tuned, and responsive to task-related variables as learning progressed. Furthermore, only after task learning, the activity of dentate granule cell ensembles represented the navigation path and predicts auditory decisions as early as when rats began to approach the goals. Finally, chemogenetic silencing of dentate gyrus suppressed task learning. Our results demonstrate that dentate granule cells gain task-relevant firing pattern through reinforcement learning and could be a potential link of sensory decisions to spatial navigation. Nature Publishing Group UK 2021-07-13 /pmc/articles/PMC8277790/ /pubmed/34257342 http://dx.doi.org/10.1038/s41598-021-93721-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Shen, Jia Yao, Pan-Tong Ge, Shaoyu Xiong, Qiaojie Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title | Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title_full | Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title_fullStr | Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title_full_unstemmed | Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title_short | Dentate granule cells encode auditory decisions after reinforcement learning in rats |
title_sort | dentate granule cells encode auditory decisions after reinforcement learning in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277790/ https://www.ncbi.nlm.nih.gov/pubmed/34257342 http://dx.doi.org/10.1038/s41598-021-93721-8 |
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